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Article

The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons

Recombinant tissue-type plasminogen activator (r-tPA/Actilyse) stands as the prevailing pharmacological solution for treating ischemic stroke patients, of whom because their endogenous circulating tPA alone is...

Paul Prunotto, Pauline Marie, Laurent Lebouvier, Yannick Hommet… in Cell Death & Disease (2024)