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Open AccessThe Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons
Recombinant tissue-type plasminogen activator (r-tPA/Actilyse) stands as the prevailing pharmacological solution for treating ischemic stroke patients, of whom because their endogenous circulating tPA alone is...
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Open AccessParvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure
Perineuronal nets (PNNs) are specialized extracellular matrix structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult, their degradation alters FS-PV-driven functions, such a...
