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Open AccessCorrection to: Histamine H2‑receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II–hypertensive mice
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Open AccessHistamine H2-receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II–hypertensive mice
Aldosterone through the mineralocorticoid receptor MR has detrimental effects on cardiovascular disease. It reduces the bioavailability of nitric oxide and impairs endothelium-dependent vasodilatation. In resi...
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Article
Deficiency of T-type voltage-gated calcium channels results in attenuated weight gain and improved endothelium-dependent dilatation of resistance vessels induced by a high-fat diet in mice
The deletion of T-type Cav3.1 channels may reduce high-fat diet (HFD)-induced weight gain, which correlates positively with obesity and endothelial dysfunction. Therefore, experiments were designed to study the i...
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Article
Activation of NQO-1 mediates the augmented contractions of isolated arteries due to biased activity of soluble guanylyl cyclase in their smooth muscle
Earlier studies on isolated arteries demonstrated that the para-quinone thymoquinone, like acute hypoxia, induces augmentation of contractions, depending on biased activity of soluble guanylyl cyclase (sGC), gene...
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Article
Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice
Impairment of endothelial function with aging is accompanied by reduced nitric oxide (NO) production. T-type Cav3.1 channels augment nitric oxide and co-localize with eNOS. Therefore, the hypothesis was that T-ty...
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Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors
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Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice
Endothelin-1 (ET-1) is essential for mammalian development and life, but it has also been implicated in increased cardiovascular risk under pathophysiological conditions. The aim of this study was to determine...
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Chapter
3′,5′-cIMP as Potential Second Messenger in the Vascular Wall
Traditionally, only the 3′,5′-cyclic monophosphates of adenosine and guanosine (produced by adenylyl cyclase and guanylyl cyclase, respectively) are regarded as true “second messengers” in the vascular wall, d...
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Article
Open AccessSodium nitrite exerts an antihypertensive effect and improves endothelial function through activation of eNOS in the SHR
Sodium nitrite (NaNO2) induces relaxation in isolated arteries partly through an endothelium-dependent mechanism involving NO-eNOS-sGC-cGMP pathway. The present study was designed to investigate the effect of chr...
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Open AccessThe cyclic nucleotide 3’,5’-cIMP produced by sGC is a second messenger in the vascular wall
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T-type Ca2+ channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure
Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxid...
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Tissues cIMPly do not lie
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Acidosis prevents and alkalosis augments endothelium-dependent contractions in mouse arteries
Changes in pH modulate the responsiveness of vascular smooth muscle cells to vasoconstrictor stimuli, but their effect on endothelium-dependent responses is unknown. Therefore, the influence of moderate change...
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Reference Work Entry In depth
Reactive Oxygen Species and Endothelium-Derived Contracting Factor (EDCF) – Partners in Endothelial Dysfunction
The augmented release of endothelium-derived contracting factor(s) is a hallmark of endothelial dysfunction. The most common endothelium-derived contracting factors (EDCFs) are produced by endothelial cyclooxy...
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The calcineurin inhibitor cyclosporine A improves lipopolysaccharide-induced vascular dysfunction but does not rescue from cardiovascular collapse in endotoxemic mice
The calcineurin inhibitor cyclosporine A (CsA) improves survival in endotoxemic mice. It was hypothesized that CsA counteracts the bradycardia and hypotension characteristic of endotoxemia. Vascular reactivity...
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Article
Open AccessEffects of probiotics in patients with diabetes mellitus type 2: study protocol for a randomized, double-blind, placebo-controlled trial
Low grade chronic inflammation is observed in patients with type 2 diabetes mellitus (T2DM). Endotoxin derived from gut bacteria may act as a potent inflammatory stimulant. Probiotics, which are believed to co...
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Article
Preparation and characterization of valsartan-loaded polyoxalate microspheres: In vitro release profiles
Valsartan, a selective angiotensin II type 1 receptor (AT1R) antagonist, has a high bioavailability. Hydrophobic polyoxalate has been suggested for use in biodegradable medical devices such as absorbable sutur...
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Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats
Postmenopausal women experience higher risks for cardiovascular diseases than age-matched men and pre-menopausal women. There is a need for better treatment strategy for estrogen-deficient-related cardiovascul...
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Regeneration of the Endothelium in Vascular Injury
The endothelium mediates relaxations (dilatations) of the underlying vascular smooth muscle cells. The endothelium-dependent relaxations are due to the release of non-prostanoid vasodilator substances. The bes...
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Article
Open AccessEndothelium-derived Vasoactive Factors and Hypertension: Possible Roles in Pathogenesis and as Treatment Targets
Endothelial cells regulate vascular tone by releasing various contracting and relaxing factors including nitric oxide (NO), arachidonic acid metabolites (derived from cyclooxygenases, lipoxygenases, and cytoch...
