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Article
Open AccessCharacterization of microglial transcriptomes in the brain and spinal cord of mice in early and late experimental autoimmune encephalomyelitis using a RiboTag strategy
Microglia play an important role in the pathogenesis of multiple sclerosis and the mouse model of MS, experimental autoimmune encephalomyelitis (EAE). To more fully understand the role of microglia in EAE we c...
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Article
Open AccessStirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells
Due to their ability to standardize key physiological parameters, stirred suspension bioreactors can potentially scale the production of quality-controlled pluripotent stem cells (PSCs) for cell therapy applic...
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Article
Open AccessA shared core microbiome in soda lakes separated by large distances
In alkaline soda lakes, concentrated dissolved carbonates establish productive phototrophic microbial mats. Here we show how microbial phototrophs and autotrophs contribute to this exceptional productivity. Am...
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Article
Open AccessGlucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells
Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma. However, reduced efficacy in severe di...
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Article
The lifelong impact of fetal growth restriction on cardiac development
Maternal nutrient restriction (MNR) is a widespread cause of fetal growth restriction (FGR), an independent predictor of heart disease and cardiovascular mortality. Our objective was to examine the development...
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Article
Open AccessRapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): exome sequencing of trios, monozygotic twins and tumours
Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) is thought to be a genetic disease caused by de novo mutations, though causative mutations have yet to be i...
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Chapter and Conference Paper
Hel** Biologists Effectively Build Workflows, without Programming
Seahawk is a browser for Moby Web services, which are online tools using a shared semantic registry and data formats. To make a wider array of tools available within Seahawk, the Daggoo system helps users adap...
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Chapter
Genomic Data Visualization: The Bluejay System
We have developed the Bluejay system, a visual environment for the visualization and comparison of genomes and associated biological data. The software system offers many innovative features that are essential...
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Article
Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism
Elicitor-induced sanguinarine accumulation in opium poppy (Papaver somniferum) cell cultures provides a responsive model system to profile modulations in gene transcripts and metabolites related to alkaloid biosy...
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Chapter and Conference Paper
Enhancing Bluejay with Scalability, Genome Comparison and Microarray Visualization
The Bluejay genome browser (Browser for Linear Units in Java™) is a flexible visualization environment for biological sequences, which is capable of producing high-quality graphical outputs (http://bluejay.uca...
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Chapter and Conference Paper
Combining a High-Throughput Bioinformatics Grid and Bioinformatics Web Services
We have created a high-throughput grid for biological sequence analysis, which is freely accessible via bioinformatics Web services. The system allows the execution of computationally intensive sequence alignm...
