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Article
Open AccessOptimised passive marker device visibility and automatic marker detection for 3-T MRI-guided endovascular interventions: a pulsatile flow phantom study
Passive paramagnetic markers on magnetic resonance imaging (MRI)-compatible endovascular devices induce susceptibility artifacts, enabling MRI-visibility and real-time MRI-guidance. Optimised visibility is cru...
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Article
Open AccessThe hazards and risks of inhaled poorly soluble particles – where do we stand after 30 years of research?
In 2006, titanium dioxide and carbon black were classified by IARC as “possibly carcinogenic to humans” and in 2017 the European Chemicals Agency’s (ECHA) Committee for Risk Assessment concluded titanium dioxi...
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Article
Open AccessAn updated review of the genotoxicity of respirable crystalline silica
Human exposure to (certain forms of) crystalline silica (CS) potentially results in adverse effects on human health. Since 1997 IARC has classified CS as a Group 1 carcinogen [1], which was confirmed in a later r...
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Article
Open AccessSilica-induced NLRP3 inflammasome activation in vitro and in rat lungs
Mineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory ...
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Article
First Magnetic Resonance Imaging-Guided Aortic Stenting and Cava Filter Placement Using a Polyetheretherketone-Based Magnetic Resonance Imaging-Compatible Guidewire in Swine: Proof of Concept
The purpose of this study was to demonstrate feasibility of percutaneous transluminal aortic stenting and cava filter placement under magnetic resonance imaging (MRI) guidance exclusively using a polyetherethe...
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Article
Actin plays a crucial role in the phagocytosis and biological response to respirable quartz particles in macrophages
The uptake of respirable quartz particles by alveolar macrophages (AM) is believed to cause an inflammatory response, which is discussed as a crucial step in quartz pathogenicity. However, little is known abou...
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Article
Induction of CYP1A1 in rat lung cells following in vivo and in vitro exposure to quartz
Respirable quartz has been classified as a human lung carcinogen, but the mechanism by which quartz exposure leads to lung cancer has not been clarified. Consistently higher risks of lung cancer are reported i...
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Article
Cellular uptake and cytotoxic potential of respirable bentonite particles with different quartz contents and chemical modifications in human lung fibroblasts
Considering the biological reactivity of pure quartz in lung cells, there is a strong interest to clarify the cellular effects of respirable siliceous dusts, like bentonites. In the present study, we investiga...
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Article
Mechanisms of neutrophil-induced DNA damage in respiratory tract epithelial cells
Reactive oxygen species (ROS) released by neutrophils have been suggested to play an important role in cancer development. Since the mechanisms underlying this effect in the respiratory tract are still unclear...
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Article
Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter
Exposure to ambient particulate matter has been reported to be associated with increased rates of lung cancer. Previously we showed that total suspended particulate matter (PM) induces oxidative DNA damage in ...
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Chapter
Mechanisms of neutrophil-induced DNA damage in respiratory tract epithelial cells
Reactive oxygen species (ROS) released by neutrophils have been suggested to play an important role in cancer development. Since the mechanisms underlying this effect in the respiratory tract are still unclear...
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Chapter
Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter
Exposure to ambient particulate matter has been reported to be associated with increased rates of lung cancer. Previously we showed that total suspended particulate matter (PM) induces oxidative DNA damage in ...
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Article
Longitudinal changes in inflammatory markers in nasal lavage of cotton workers
Objectives: The aim of this study was to evaluate time-related changes in inflammatory markers in nasal lavage (NAL) in relation to endotoxin exposure and lung function changes.
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Article
Oxidative DNA damage in peripheral blood lymphocytes of coal workers
Reactive oxygen species are important mediators of both mineral dust-induced (malignant) lung disease and in vitro DNA damage. Therefore, we studied in vivo oxidative DNA damage in coal workers who had been ch...
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Article
Evaluation of serum type III procollagen peptide as an exposure marker in retired coal workers
Serum type III procollagen peptide (PIIIP), a degradation product of the type III collagen precursor, has been put forward as an exposure marker for mineral dust. We evaluated PIIIP levels as a marker of expos...
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Article
Respiratory effects and serum type III procollagen in potato sorters exposed to diatomaceous earth
Exposure to diatomaceous earth with low crystalline silica content (< 1%) is rarely reported to cause pneumoconiotic disease, whereas airway obstruction and bronchitis are more frequently reported. We investig...
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Article
Evaluation of urinary excretion of l-hydroxypyrene and thioethers in workers exposed to bitumen fumes
Biological monitoring of exposure to bitumen fumes during road-paving operations was carried out. In order to evaluate the biological uptake of the workers, the nonselective urinary thioether assay and a selec...
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Chapter and Conference Paper
Biological Monitoring of Exposure to Bitumen Fumes During Road Paving Operations
Bitumens and fumes contain relatively small amounts of polycyclic aromatic hydrocarbons (PAH), some of which are known to be carcinogenic or cocarcinonic (Brandt 1985). Workers may be exposed to bitumen fumes ...
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Chapter
Asbestos Mediated Gene Expression in Rat Lung
The term “asbestos” refers to a family of hydrated silicates with an aspect (length to diameter) ratio of > 3:1 as defined by regulatory policy in the United States. Physicochemical characteristics vary consid...
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Article
Abstracts of papers Pharmacological meeting
