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  1. No Access

    Article

    Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

    Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations—such as melanoma, smoking-indu...

    Nikolaos Zacharakis, Harshini Chinnasamy, Mary Black, Hui Xu… in Nature Medicine (2018)

  2. No Access

    Article

    Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

    Steven Rosenberg and colleagues report that PD-1 is a biomarker of CD8+ T cells in the blood that recognize mutated neoantigens in melanoma.

    Alena Gros, Maria R Parkhurst, Eric Tran, Anna Pasetto, Paul F Robbins… in Nature Medicine (2016)

  3. No Access

    Article

    Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

    Identifying tumor-associated T cell epitopes can be laborious. Robbins et al. now report that they used whole-exome sequence data to identify mutated peptides from tumor antigens that are recognized by tumor-infi...

    Paul F Robbins, Yong-Chen Lu, Mona El-Gamil, Yong F Li, Colin Gross… in Nature Medicine (2013)