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Article
Open AccessUsing patient-derived tumor organoids from common epithelial cancers to analyze personalized T-cell responses to neoantigens
Adoptive cell transfer of tumor-infiltrating lymphocytes (TIL) can mediate durable complete responses in some patients with common epithelial cancers but does so infrequently. A better understanding of T-cell ...
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Article
A machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types
Tumor neoepitopes presented by major histocompatibility complex (MHC) class I are recognized by tumor-infiltrating lymphocytes (TIL) and are targeted by adoptive T-cell therapies. Identifying which mutant neoe...
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Article
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations—such as melanoma, smoking-indu...
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Article
The oblique high tibial osteotomy technique without bone removal and with rigid blade plate fixation for the treatment of medial osteoarthritis of the varus knee: medium and long-term results
Several high tibial osteotomy (HTO) surgical techniques for the treatment of medial osteoarthritis of the varus knee have been reported. Their main objectives are the achievement of the precise correction that...
