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Article

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via...

Marine Berquez, Zhiyong Chen, Beatrice Paola Festa, Patrick Krohn… in Nature Communications (2023)