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    Article

    The wmN1 Enhancer Region of the Mouse Myelin Proteolipid Protein Gene (mPlp1) is Indispensable for Expression of an mPlp1-lacZ Transgene in Both the CNS and PNS

    The myelin proteolipid protein gene (PLP1) encodes the most abundant protein in CNS myelin. Expression of the gene must be strictly regulated, as evidenced by human X-linked leukodystrophies resulting from variat...

    Pankaj Patyal, Neriman T. Kockara, Patricia A. Wight in Neurochemical Research (2020)

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    Article

    Expression of a Myelin Proteolipid Protein (Plp)-lacZ Transgene is Reduced in both the CNS and PNS of Plp jp Mice

    Jimpy (Plp jp ) is an X-linked recessive mutation in mice that causes CNS dysmyelination and early death in affected males. It results from a po...

    Patricia A. Wight, Cynthia S. Duchala, H. Elizabeth Shick… in Neurochemical Research (2007)

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    Transgenic Models for Investigating Oligodendrocyte Differentiation and Myelin Formation

    The myelin membrane is a highly specialized extension of the oligodendroglial plasma membrane, which surrounds axons and forms a tightly compacted multilamellar structure1. Myelin has a relatively simple protein ...

    Wendy B. Macklin, Patricia A. Wight… in A Multidisciplinary Approach to Myelin Dis… (1994)