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  1. Article

    Open Access

    Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening

    Malaria parasites like Plasmodium falciparum multiply in red blood cells (RBC), which are cleared from the bloodstream by the spleen when their deformability is altered. Drug-induced stiffening of Plasmodium falc...

    Mario Carucci, Julien Duez, Joel Tarning, Irene García-Barbazán… in Nature Communications (2023)

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  2. No Access

    Article

    High-throughput microsphiltration to assess red blood cell deformability and screen for malaria transmission–blocking drugs

    Here, the authors use microsphiltration for the discovery of compounds that stiffen Plasmodium falciparum gametocytes, by filtering compound-exposed gametocytes through microsphere layers in 384-well plates.

    Julien Duez, Mario Carucci, Irene Garcia-Barbazan, Matias Corral… in Nature Protocols (2018)

  3. Article

    Open Access

    Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria

    Sickle-cell trait (HbAS) reduces falciparum malaria risk and suppresses parasitaemia. Although several candidate mechanisms have been proposed, their epidemiological, clinical and experimental correlates have ...

    Seidina A. S. Diakité, Papa Alioune Ndour, Valentine Brousse… in Malaria Journal (2016)

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  4. No Access

    Living Reference Work Entry In depth

    Role of the Spleen in Human Malaria

    Papa Alioune Ndour, Innocent Safeukui, Seidina Diakité… in Encyclopedia of Malaria