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Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents

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  1. Article

    Open Access

    Author Correction: CD98hc is a target for brain delivery of biotherapeutics

    Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan… in Nature Communications (2023)

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  2. Article

    Open Access

    CD98hc is a target for brain delivery of biotherapeutics

    Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the ...

    Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan… in Nature Communications (2023)

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  3. Article

    Open Access

    NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

    T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a dismal prognosis in patients with resistant or relapsed disease. Although NOTCH is a known driver in T-ALL, its clin...

    Inês Pinto, Mafalda Duque, Joana Gonçalves, Padma Akkapeddi… in Oncogene (2020)

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  4. Article

    Open Access

    A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

    T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer for which treatment options often result in incomplete therapeutic efficacy and long-term side-effects. Interleukin 7 (IL-7) an...

    Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho… in Leukemia (2019)

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