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Open AccessFunctions of the RIP kinase family members in the skin
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress signals. In response to several extracellular and/or intracellula...
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Open AccessNeutralization of Junín virus by single domain antibodies targeted against the nucleoprotein
The syndrome viral haemorrhagic fever (VHF) designates a broad range of diseases that are caused by different viruses including members of the family Arenaviridae. Prophylaxis for Argentine Haemorrhagic Fever (AH...
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Nanos genes and their role in development and beyond
The hallmark of Nanos proteins is their typical (CCHC)2 zinc finger motif (zf-nanos). Animals have one to four nanos genes. For example, the fruit fly and demosponge have only one nanos gene, zebrafish and humans...
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Metazoan evolution of the armadillo repeat superfamily
The superfamily of armadillo repeat proteins is a fascinating archetype of modular-binding proteins involved in various fundamental cellular processes, including cell–cell adhesion, cytoskeletal organization, ...
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MALT1 is not alone after all: identification of novel paracaspases
Paracaspases and metacaspases are two families of caspase-like proteins identified in 2000. Up until now paracaspases were considered a single gene family with one known non-metazoan paracaspase in the slime m...
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Evolution of Cadherins and Associated Catenins
During more than 600 Ma of multicellular animal evolution, the cadherin superfamily has become strikingly diverse, both structurally and functionally. Cadherins are typically transmembrane proteins with an ect...
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A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes
Tiels et al. identify a bacterial glycosidase that facilitates improved modification of N-glycans on the Pompe disease enzyme α-glucosidase.
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Evolutionary functional analysis and molecular regulation of the ZEB transcription factors
ZEB1 and ZEB2, which are members of the ZEB family of transcription factors, play a pivotal role in the development of the vertebrate embryo. However, recent evidence shows that both proteins can also drive th...
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Open AccessText-mining assisted regulatory annotation
Decoding transcriptional regulatory networks and the genomic cis-regulatory logic implemented in their control nodes is a fundamental challenge in genome biology. High-throughput computational and experimental an...