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Article
Lack of awareness in both patients and physicians contributes to a high rate of late presentation in a South West German HIV patient cohort
To assess rate of late presentation with HIV in Southwestern Germany and to identify patient characteristics correlated with CD4 nadir.
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Article
Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors
Apoptosis signaling is involved in both physiological tissue homeostasis and acute and chronic diseases. The role of regulatory apoptosis signaling molecules and their organ-specific functions are less defined...
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Article
Therapie des hepatozellulären Karzinoms
Das hepatozelluläre Karzinom (HCC) ist mittlerweile die häufigste Todesursache bei Patienten mit Leberzirrhose. Es ist damit zurechnen, dass die Inzidenz in den kommenden Jahren auch in der westlichen Welt wei...
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Article
Interdisziplinäres Vorgehen bei einem Patienten mit IgG4-assoziiertem Morbus Mikulicz
Das klinische Bild einer vergrößerten Glandula submandibularis und/oder einer vergrößerten Glandula lacrimalis führt häufig zu differenzialdiagnostischen Schwierigkeiten. Vonseiten der Rheumatologie sollte ein...
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Article
Open AccessDiabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells
The endemic occurrence of obesity and the associated risk factors that constitute the metabolic syndrome have been predicted to lead to a dramatic increase in chronic liver disease. Non-alcoholic steatohepatit...
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Article
The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis
Lethal giant larvae proteins have key roles in regulating polarity in a variety of cell types and function as tumour suppressors. A transcriptional programme initiated by aberrant Snail expression transforms e...
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Article
Open AccessMelatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells
Melatonin induces apoptosis in many different cancer cell lines, including hepatocellular carcinoma cells. However, the responsible pathways have not been clearly elucidated. A member of the forkhead transcrip...
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Article
Diagnostik und Therapie des Ösophaguskarzinoms
Die Prognose des Ösophaguskarzinoms ist im fortgeschrittenen Stadium schlecht. Das zunehmende Verständnis der Tumorbiologie des Plattenepithel- und Adenokarzinoms der Speiseröhre sowie die Kenntnis der entspre...
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Article
Neues zur Sonographie in der Gastroenterologie (Teil 2)
Im vorliegenden zweiten Teil wird die endoskopische Kontrastmittelsonographie diskutiert, die eine Anwendung in Bereichen ermöglicht, die dem herkömmlichen transabdominellen Ultraschall nicht zugänglich sind. ...
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Article
Neues zur Sonographie in der Gastroenterologie (Teil 1)
Der Stellenwert der Sonographie hat innerhalb der Gastroenterologie in den letzten Jahren durch die Etablierung neuer Verfahren wie z. B. Kontrastmittelultraschall an Bedeutung zugenommen. In dem Übersichtsart...
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Article
Organprotektive Intensivtherapie und Simulatortraining
Die Bereitschaft zur Organspende ist in Deutschland nach wie vor unzureichend. Bei Weitem nicht alle Patienten auf den Wartelisten erhalten rechtzeitig ein geeignetes Spenderorgan. Die adäquate intensivmedizin...
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Article
Erratum: Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
Nat. Med. 6, 583–588 (2000); corrected after print 4 November 2010 In the version of this article initially published, the fourth image in Figure 4b was a duplication of the third image. The error has been cor...
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Chapter and Conference Paper
Does expression of receptor tyrosine kinases in gastric adenocarcinoma correlate with clinicopathological parameters?
Introduction: The prognosis for patients with gastric cancer depends on the stage of the disease. Radical surgery and lymph node dissection represent the only curative intent and are the standard...
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Book and Conference Proceedings
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Article
Endoluminaler Ultraschall des Gastrointestinaltraktes
Neue endoluminale, bildgebende Techniken nehmen einen zunehmenden klinischen Stellenwert in der Diagnostik und Therapie verschiedenster gastrointestinaler Erkrankungen ein. Die klassische Endosonographie (EUS)...
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Article
Genetic and environmental contributions to plasma C-reactive protein and interleukin-6 levels – a study in twins
Elevated baseline levels of acute-phase proteins such as C-reactive protein (CRP) or cytokines like interleukin-6 (IL-6) are known risk factors for atherosclerosis and cardiovascular disease (CVD) events. Howe...
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Article
Open AccessDissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4
In different tumour entities, expression of the chemokine receptor 4 (CXCR4) has been linked to tumour dissemination and poor prognosis. Therefore, we evaluated, if the expression of CXCR4 exerts similar effec...
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Article
Open AccessA phase I/II multicentric trial of gemcitabine and epirubicin in patients with advanced pancreatic carcinoma
Potential synergistic interaction between gemcitabine (GEM) and epirubicin (EPI) in pancreatic cancer have been described previously. The maximum-tolerated dose in this trial was GEM 1000 mg m−2 and EPI 45 mg m−2
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Article
Endomikroskopie
Die Endomikroskopie eröffnet die mikroskopische Betrachtung der Schleimhaut und Schleimhautoberfläche des Gastrointestinaltrakts während der laufenden Endoskopie in hoher Auflösung mittels lasergestützter, kon...
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Article
Open AccessRandomised phase II evaluation of irinotecan plus high-dose 5-fluorouracil and leucovorin (ILF) vs 5-fluorouracil, leucovorin, and etoposide (ELF) in untreated metastatic gastric cancer
An open-label randomised comparison of efficacy and tolerability of irinotecan plus high-dose 5-fluorouracil (5-FU) and leucovorin (LV) (ILF) with etoposide plus 5-FU/LV (ELF) in patients with untreated metast...
