24 Result(s)

Article

Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation

F De Falco, R Sabatini, F Falzetti, M Di Ianni, P Sportoletti, S Baldoni… in Leukemia (2015)

Article

A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia

P Sportoletti, S Baldoni, B Del Papa, P Aureli, E Dorillo, L Ruggeri, S Plebani… in Leukemia (2014)

Article

Influence of the KDEL signal, DMSO and mannitol on the production of the recombinant antibody 14D9 by long-term Nicotiana tabacum cell suspension culture

We have established two transgenic cell suspension culture lines of Nicotiana tabacum that express the catalytic antibody 14D9 as a secretory product (sec-Ab) or as a KDEL-tagged product in the endoplasmic reticu...

J. López, F. Lencina, S. Petruccelli… in Plant Cell, Tissue and Organ Culture (PCTO… (2010)

Article

Evidence of Dual Sexual Transmission of Multi-resistant HIV with Two Years Persistence of Resistance to NRTI and NNRTI: a Case Report

A case report of dual sexual transmission, with secondary transmission from naïve to naïve patient, of HIV harbouring K103N and L100I mutations, conferring full non-nucleoside reverse transcriptase inhibitor (...

M. Zaccarelli, P. Marconi, U. Visco-Comandini, G. Liuzzi, P. Sette… in Infection (2008)

Article

Observational Study on HIV-Infected Subjects Failing HAART Receiving Tenofovir Plus Didanosine as NRTI Backbone

We evaluated the efficacy of tenofovir (TDF) – and didanosine (ddI)-containing backbones in HIV-infected experienced subjects. We included in the study 245 subjects who started a TDF/ddI-containing HAART with ...

M. Bongiovanni, N. Gianotti, E. Chiesa, P. Nasta, P. Cicconi, A. Capetti… in Infection (2007)

Article

Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth

There is growing evidence that combinations of antiangiogenic proteins with other antineoplastic treatments such as chemo- or radiotherapy and suicide genes-mediated tumor cytotoxicity lead to synergistic effe...

E Berto, A Bozac, I Volpi, I Lanzoni, F Vasquez, N Melara… in Cancer Gene Therapy (2007)

Article

HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG_35–55-induced experimental autoimmune encephalomyelitis in C57BL/6 mice

Primary proinflammatory cytokines, such as IL-1β, play a crucial pathogenic role in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE), and may represent, therefore, a suitabl...

R Furlan, A Bergami, E Brambilla, E Butti, M G De Simoni, M Campagnoli… in Gene Therapy (2007)

Article

Development and application of replication-incompetent HSV-1-based vectors

The replication-incompetent HSV-1-based vectors are herpesviruses in which genes that are ‘essential’ for viral replication have been either mutated or deleted. These deletions have substantially reduced their...

E Berto, A Bozac, P Marconi in Gene Therapy (2005)

Article

Sanitary Monitoring Models for Wild Ungulate Stock Farms in Tuscany

A. Martini, P. Marconi, M. P. Ponzetta, A. Giorgetti… in Veterinary Research Communications (2005)

Article

Effects of defective herpes simplex vectors expressing neurotrophic factors on the proliferation and differentiation of nervous cells in vivo

Neurotrophic factors (NTFs) are known to govern the processes involved in central nervous system cell proliferation and differentiation. Thus, they represent very attractive candidates for use in the study and...

P Marconi, S Zucchini, E Berto, A Bozac, B Paradiso, G Bregola, C Grassi… in Gene Therapy (2005)

Chapter and Conference Paper

Is Fluoroscopic Electrode Positioning Improving the Clinical Efficacy of External Biphasic Cardioversion in Patients with Atrial Fibrillation?

The use of external direct current (DC) transthoracic capacitor discharge to terminate atrial fibrillation (AF) was first reported in 1962 by Lown et al. [1]. However, external DC cardioversion with a monophasic ...

P. Marconi, F. Sarro, C. Marioni… in New Advances in Heart Failure and Atrial F… (2003)

Article

Genetically modified CD34⁺ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model

To develop a cellular vehicle able to reach systemically disseminated areas of angiogenesis, we sought to exploit the natural tropism of circulating endothelial progenitor cells (EPCs). Primate CD34⁺ EPCs were ge...

J Gómez-Navarro, J L Contreras, W Arafat, X L Jiang, D Krisky, T Oligino… in Gene Therapy (2000)

Article

Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer in vitro and in vivo

We report here the construction and the use of two replication-defective herpes simplex virus vectors, SH FGF-2 and TH FGF-2, which efficiently transfer and express the cDNA for fibroblast-growth-factor-2 (FGF...

P Marconi, M Simonato, S Zucchini, G Bregola, R Argnani, D Krisky… in Gene Therapy (1999)

Chapter and Conference Paper

Long-Term Treatment with Amiodarone for the Prevention of Sudden Death in Patients with Dilated Cardiomyopathy

There is considerable controversy about the treatment of asymptomatic ventricular arrhythmias in patients with congestive heart failure [1]. Antiarrhythmic therapy has been reported either to prolong survival ...

M. Ciaccheri, G. Castelli, M. Nannini, V. Troiani… in Advances in Cardiomyopathies (1990)