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  1. Article

    Erratum: Global threats to human water security and river biodiversity

    Nature 467, 555–561 (2010) In this Article, the full present address for author P. B. McIntyre was inadvertently missing from the bottom of the page. The correct present address is: Center for Limnology, Unive...

    C. J. Vörösmarty, P. B. McIntyre, M. O. Gessner, D. Dudgeon, A. Prusevich… in Nature (2010)

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    Article

    Global threats to human water security and river biodiversity

    Protecting the world’s freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodivers...

    C. J. Vörösmarty, P. B. McIntyre, M. O. Gessner, D. Dudgeon, A. Prusevich… in Nature (2010)

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    Chapter

    Plasma Uridine as well as Uric Acid is Elevated Following Fructose Loading

    The hyperuricaemia following fructose loading was first demonstrated by Perheen-tupa and Raivio in 1967 (1). Subsequent studies (reviewed in 2) established that this elevation of plasma and urine uric acid con...

    P. M. Davies, H. A. Simmonds, B. Singer… in Purine and Pyrimidine Metabolism in Man IX (1998)

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    Article

    Urinary uracil concentrations are a useful guide to genetic disorders associated with neurological deficits and abnormal pyrimidine metabolism

    Elevated urinary uracil concentrations are characteristic of genetic deficiencies of enzymes catalysing the first two steps of the pyrimidine degradative pathway (Van Gennip et al 1993), dihydropyrimidine dehy...

    P.M. Davies, L.D. Fairbanks, J.A. Dulby… in Journal of Inherited Metabolic Disease (1997)

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    Article

    Abstracts of poster presentations

    A. B. Agostinho, F. Rosi, A. Tabucchi, F. Carlucci… in Pharmacy World and Science (1993)

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    Article

    Dihydropyrimidinase deficiency presenting in infancy with severe developmental delay

    M. J. Henderson, K. Ward, H. A. Simmonds… in Journal of Inherited Metabolic Disease (1993)

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    Chapter and Conference Paper

    Dihydropyrimidinuria Presenting in Childhood with Severe Developmental Retardation

    Dihydropyrimidinase (5,6-dihydropyrimidine amidohydrolase; EC 3.5.2.2), is the second enzyme involved in the breakdown of the pyrimidine bases uracil and thymine and catalyses the degradation of dihydrouracil ...

    K. Ward, M. J. Henderson, H. A. Simmonds… in Molecular Genetics, Biochemistry and Clini… (1993)

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    Chapter

    Raised IMP-Dehydrogenase Activity in the Erythrocytes of a Case of Purine Nucleoside Phosphorylase (PNP) Deficiency

    The presenting features of PNP deficiency may be neurological, usually a mild non-progressive spastic diplegia, or related to immunodeficiency which predominantly affects T-lymphocytes. Patients usually die of...

    G. Morgan, S. Strobel, C. Montero… in Purine and Pyrimidine Metabolism in Man VII (1991)

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    Chapter

    An Improved Screening Method for Inherited Disorders of Purine and Pyrimidine Metabolism by HPLC

    HPLC has been used extensively in the identification of genetic disorders of purine and pyrimidine metabolism. Some of the problems which may be encountered in assessing patients, for example on high caffeine ...

    P. M. Davies, M. B. McBride, H. A. Simmonds in Purine and Pyrimidine Metabolism in Man VII (1991)

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    Chapter

    Purine Metabolites in Uraemia

    Many investigators have described the large number of unknown solutes of low molecular weight, within the purine range, which accumulate in the plasma during progressive reduction in renal function (1). Their ...

    H. A. Simmonds, J. S. Cameron, G. S. Morris, L. D. Fairbanks, P. M. Davies in Uremic Toxins (1987)