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Article
Classification of drugs for teratogenic risk
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Article
The pharmacokinetics and pharmacodynamics of metoprolol after conventional and controlled-release administration in combination with hydrochlorothiazide in healthy volunteers
We have studied a controlled-release formulation containing metoprolol 100 mg and hydrochlorothiazide 12.5 mg. We compared the pharmacokinetics of both substances and the pharmacodynamics of metoprolol with th...
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Article
Adverse event monitoring in clinical trials of felodipine and omeprazole
Although most clinical trials encompass aspects of safety, methods for assessing the safety of a drug by recording adverse events have been poorly studied. It has been suggested that adverse events rather than...
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Article
Lack of effect of omeprazole treatment on steady-state plasma levels of metoprolol
In a randomised double-blind crossover study, seven healthy males were concomitantly given metoprolol 100 mg o. d. as a controlled release formulation, and omeprazole 40 mg o. d. or placebo, for 8 days. Plasma...
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Article
The effect of hydralazine on steady-state plasma concentrations of metoprolol in pregnant hypertensive women
We have studied the plasma concentrations levels of metoprolol after its twice daily administration in a dose of 50 mg for 4 days in ten, hypertensive pregnant women to the during monotherapy and in combinatio...
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Article
Pharmacokinetic and pharmacodynamic properties of a new controlled-release formulation of metoprolol: A comparison with conventional tablets
The pharmacokinetic and pharmacodynamic properties of a new multiple-unit, controlled-release (CR) formulation of metoprolol1 (metoprolol succinate, 95 mg once daily), which has almost constant (zero-order) relea...
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Article
Pharmacokinetics and pharmacodynamics of controlled-release metoprolol: A comparison with atenolol
Pharmacokinetic and pharmacodynamic properties of a new controlled-release (CR) formulation of metoprolol1 have been compared with those of atenolol2. Metoprolol CR (100 mg and 200 mg), atenolol (50 mg and 100 mg...
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Article
Clinical Pharmacokinetics of Felodipine
Felodipine is completely absorbed from the gastrointestinal tract. However, the amount reaching the systemic circulation is reduced to about 15% because of first-pass degradation. The bioavailability is consta...
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Article
Disposition of the adrenergic blocker metoprolol and its metabolite OH-metoprolol in maternal plasma, amniotic fluid and capillary blood of the neonate
Seven women were treated with metoprolol 50–100 mg twice daily for hypertension in pregnancy. The disposition of metoprolol and one of its metabolites alfa-OH-metoprolol was studied in venous plasma and amniot...
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Article
Absorption, Distribution and Elimination of Felodipine in Man
The objectives of these investigations were to study the absorption and disposition characteristics of felodipine in young healthy male volunteers following acute administration of different intravenous and or...
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Article
Acute Diuretic/Natriuretic Properties of Felodipine in Man
The natriuretic/diuretic effect of felodipine was investigated in 2 studies. The first was performed as an open study using intravenous and oral felodipine in healthy male subjects. The second was a double-bli...
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Article
Development of dopamine autoreceptors in the postnatal rat brain
The behavioural and biochemical effects of racemic 3-PPP (3-[3-hydroxyphenyl]-N-n-propyl-piperidine) and its enantiomers was studied in develo** rats, aged 1–28 days. All three compounds exhibit dopamine (DA...
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Article
Central GABA mechanisms during postnatal development in the rat: Neurochemical characteristics
Various biochemical characteristics of the develo** GABA system was studied in rats from 1 to 60 days of age. Endogenous GABA concentrations were high in the limbic system, midbrain, brain stem and spinal co...
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Article
Pharmacokinetics of metoprolol in healthy, elderly, non-smoking individuals after a single dose and two weeks of treatment
The effect of long-term treatment on the absorption and dispsoition of metoprolol has been evaluated in 8 healthy, non-smoking, elderly individuals (mean age 74.5 years) and in a control group of 8 healthy, yo...
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Article
Pharmacokinetics of metoprolol and its metabolite α-OH-metoprolol in healthy, non-smoking, elderly individuals
The absorption and disposition of metoprolol have been evaluated in 10 healthy, non-smoking, elderly individuals (mean age 73.1 years) by simultaneous determination of [3H]-metoprolol and unlabelled metoprolol. T...
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Article
Effect of gammahydroxybutyric acid on serotonin synthesis, concentration and metabolism in the develo** rat brain
5-HT synthesis, levels and degradation were investigated in the whole brain and regional brain areas in 4,14, and 28 days old rats after administration of gammahydroxybutyric acid (GHBA). 5-HT synthesis was in...
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Article
Effect of gammahydroxybutyric acid on catecholamine synthesis and utilization in the develo** rat brain
Gammahydroxybutyric acid (GHBA) was administered subcutaneously, 750mg/kg, to 1, 4, 14 and 28 days old rats 30 or 90 min before sacrifice. Whole brain and regional brain levels of tyrosine, dopamine (DA) and n...
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Article
Pharmacokinetics of Metoprolol in Patients with Hepatic Cirrhosis
The selective β1-adrenoceptor antagonist metoprolol is eliminated primarily by hepatic metabolism and usually less than 5% of an oral dose is excreted unchanged in the urine.
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Article
Pharmacokinetic studies in man of the selective beta1-adrenoceptor agonist, prenalterol
The pharmacokinetics of prenalterol, a selective β1-adrenoceptor agonist, has been studied in healthy subjects, by following the plasma concentration and urinary excretion of the unchanged compound and its total ...
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Article
Serotoninergic development in the postnatal rat brain
Various characteristics of the develo** serotoninergic system in the brain of rats aged 1 to 28 days were studied biochemically.
