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Article
Open AccessLeft cardiac sympathetic denervation in the Netherlands for the treatment of inherited arrhythmia syndromes
Treating therapy-resistant patients with inherited arrhythmia syndromes can be difficult and left cardiac sympathetic denervation (LCSD) might be a viable alternative treatment option. We provide an overview o...
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Chapter and Conference Paper
Symbolic Analysis of Heart Period and QT Interval Variabilities in LQT1 Patients
Heart period and QT interval variabilities carry important information about the state of the autonomic nervous system. Autonomic function is impaired in the long QT syndrome type 1 (LQT1) and this impairment ...
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Article
Vagal stimulation for heart diseases: from animals to men. An example of translational cardiology
A significant series of experimental and clinical studies have demonstrated the close association between reduced vagal reflexes (baroreflex sensitivity, BRS) and increased sudden and non-sudden cardiovascular...
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Chapter
ICD for the Long QT Syndrome: Which Indications, Complications, and Results?
There is a high and in many cases inappropriate use of ICDs in patients with long QT syndrome with syncope. The pros and cons of the ICD and of the other available therapies should be clearly explained to all ...
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Chapter and Conference Paper
The Link Between SIDS and Long QT Syndrome: from Theory to Evidence
For reasons not immediately obvious, the suggestions made over the years that cardiac mechanisms and, specifically, life-threatening arrhythmias [1, 2] might account for a significant portion of cases of sudde...
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Chapter and Conference Paper
Post-Infarction: When and How to Use Amiodarone
The choice of an antiarrhythmic drug to reduce the risk for sudden cardiac death after an acute myocardial infarction should be left to neither chance nor personal preference. This concept, not mindboggling bu...
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Chapter and Conference Paper
Gene Therapy for Long QT Syndrome: Fact or Fiction?
For many years the therapy for long QT syndrome (LQTS) has been based on simple and sound principles [1, 2]. In essence, therapy had been guided by the time-honored concept that it has to reflect understanding...
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Chapter
Long QT Syndrome: from Molecular Biology to Clinical Management
The last few years have witnessed a dramatic progress in the molecular biology of the congenital long QT syndrome (LQTS). The impact of these discoveries on the understanding of LQTS, and also of other disease...
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Chapter and Conference Paper
What Have We Learned from the SWORD Trial? Can Potassium Channel Blockers Reduce Sudden Cardiac Death?
On November 1, 1994, the SWORD (Survival With Oral D-sotalol) trial was terminated by the Steering Committee because of an excess mortality among the patients randomized to d-sotalol. Five years after the early t...
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Article
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
Genetic factors contribute to the risk of sudden death from cardiac arrhythmias. Here, positional cloning methods establish KVLQT1 as the chromosome 11-linked LQT1 gene responsible for the most common inherited c...
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Chapter
Influence of the Autonomic Nervous System on the Action of Antiarrhythmic Drugs
The repeated failures of a variety of antiarrhythmic drugs in preventing sudden cardiac death, particularly among post myocyardial infarction (MI) patients, have eventually turned the interest toward arrhythmo...
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Chapter and Conference Paper
Paroxysmal Atrial Fibrillation and the Autonomic Nervous System
The autonomic nervous system has profound influences on cardiac elec-trophysiology (Schwartz et al. 1978; Corr et al. 1986; Schwartz and Priori 1990), and alterations in sympathetic (Schwartz et al. 1978, 1984...
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Chapter and Conference Paper
Sympathetic Nervous System and Malignant Arrhythmias: Evidence for Further Links
The importance of the autonomic nervous system in the genesis of cardiac arrhythmias has become progressively more evident [4, 32]. Clinical and experimental observations have brought new insights into the rel...
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Chapter and Conference Paper
Catecholamine-Dependent Cardiac Arrhythmias: Mechanisms and Implications
Although the arrhythmogenic role of sympathetic activation acting over an ischemic substrate has been established [1, 2], the mechanisms involved remain largely speculative. In fact, due to their electrophysio...
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Chapter
Adrenergic Arrhythmogenesis and the Long Q-T Syndrome
It has become progressively evident that increases in sympathetic activity favour the onset of malignant cardiac arrhythmias, particularly when acting in a diseased myocardium (Schwartz and Stone 1982; Corr et al...
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Article
Comparative Evaluation of Antiarrhythmic Therapy
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Chapter
Clinical Clues and Experimental Evidences of the Neuro-Humoral Interpretation of Cardiac Arrhythmias
The critical role of the autonomic nervous system in the genesis of cardiac arrhythmias has been repeatedly demonstrated at clinical and at experimental level. This is particularly true for life-threatening ar...
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Chapter
The Long QT Syndrome
The still inadequate but increasing awareness of the existence of the idiopathic long QT syndrome (LQTS) has provided ample evidence that, as suggested by many, this disease is far from being rare. This notion...
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Article
Tonic afferent sympathetic activity from the heart
Nous avons enregistré dans les nerfs sympathiques la décharge de fibres afférentes isolées provenant de chacune des cavités cardiaques. Cette décharge était en rapport avec les événements hémodynamiques qui av...
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Article
Activation of cardiac vagal receptors during myocardial ischemia
La décharge de fibres vagales d'origine cardiaque est augmentée au cours d'une réduction du flux sanguin dans l'artère coronaire de gauche. Toutefois cette excitation n'a lieu que lorsque le coeur est déjà déf...
