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  1. No Access

    Article

    Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway

    Ibrutinib, a covalent inhibitor of Bruton Tyrosine Kinase (BTK), is approved for treatment of patients with relapsed/refractory or treatment-naïve chronic lymphocytic leukemia (CLL). Besides directly inhibitin...

    K Kondo, H Shaim, P A Thompson, J A Burger, M Keating, Z Estrov, D Harris… in Leukemia (2018)

  2. No Access

    Article

    Umbilical cord blood graft engineering: challenges and opportunities

    We are entering a very exciting era in umbilical cord blood transplantation (UCBT), where many of the associated formidable challenges may become treatable by ex vivo graft manipulation and/or adoptive immunother...

    P A Thompson, K Rezvani, C M Hosing, B Oran, A L Olson… in Bone Marrow Transplantation (2015)

  3. No Access

    Article

    A comparison of the direct cost of care in an open-bay and single-family room NICU

    This research examined the proposition that the direct costs of care were no different in an open-bay (OPBY) as compared with a single-family room (SFR) neonatal intensive care (NICU) environment.

    D C Stevens, P A Thompson, C C Helseth, B Hsu, M Akram Khan… in Journal of Perinatology (2014)

  4. No Access

    Article

    Bortezomib added to high-dose melphalan as pre-transplant conditioning is safe in patients with heavily pre-treated multiple myeloma

    P A Thompson, H M Prince, J F Seymour, D Ritchie, K Stokes… in Bone Marrow Transplantation (2011)

  5. No Access

    Article

    Plasma and cerebrospinal fluid pharmacokinetics of MP470 in non-human primates

    MP470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret that is being evaluated as an anticancer agent. The plasma and cerebrospinal fluid (...

    P. A. Baxter, P. A. Thompson, L. M. McGuffey… in Cancer Chemotherapy and Pharmacology (2011)

  6. No Access

    Chapter

    Breast Cancer Prevention

    Early detection, combined with targeted and more effective therapies, has led to reductions in breast cancer related deaths. Approximately 90% of women diagnosed with breast cancer in the US today are disease ...

    P. A. Thompson, A. T. Stopeck in Fundamentals of Cancer Prevention (2008)

  7. Article

    Lymphoid Hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD→NOD-scid adoptive T cell transfer

    Sustained antibody-mediated inhibition of tumor necrosis factor (TNF) activity offers protection against Type I (insulin-dependent) diabetes mellitus in non-obese diabetic (NOD) mice. The mechanism of this ef...

    G. R. Brown, M. D. Silva, P. A. Thompson, B. Beutler in Diabetologia (1998)

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