42 Result(s)

Article

Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway

Ibrutinib, a covalent inhibitor of Bruton Tyrosine Kinase (BTK), is approved for treatment of patients with relapsed/refractory or treatment-naïve chronic lymphocytic leukemia (CLL). Besides directly inhibitin...

K Kondo, H Shaim, P A Thompson, J A Burger, M Keating, Z Estrov, D Harris… in Leukemia (2018)

Article

Water based nanofluids for automotive applications

This paper presents a recent work on enhanced heat transfer properties of carboxylated water based nanofluids and their corrosive behavior for suitability to automotive conditions. Water mixed with Sebacic aci...

V. Srinivas, Ch. V. K. N. S. N. Moorthy… in Journal of Mechanical Science and Technolo… (2015)

Article

Umbilical cord blood graft engineering: challenges and opportunities

We are entering a very exciting era in umbilical cord blood transplantation (UCBT), where many of the associated formidable challenges may become treatable by ex vivo graft manipulation and/or adoptive immunother...

P A Thompson, K Rezvani, C M Hosing, B Oran, A L Olson… in Bone Marrow Transplantation (2015)

Article

A comparison of the direct cost of care in an open-bay and single-family room NICU

This research examined the proposition that the direct costs of care were no different in an open-bay (OPBY) as compared with a single-family room (SFR) neonatal intensive care (NICU) environment.

D C Stevens, P A Thompson, C C Helseth, B Hsu, M Akram Khan… in Journal of Perinatology (2014)

Article

Primary production and phytoplankton community structure during a winter shelf-scale phytoplankton bloom off Western Australia

Regions of high primary production along the oligotrophic west coast of Australia between 34 and 22°S in May–June 2007 (midway through the annual phytoplankton bloom) were found around mesoscale features of th...

M. J. Lourey, P. A. Thompson, M. J. McLaughlin, P. Bonham, M. Feng in Marine Biology (2013)

Article

Bortezomib added to high-dose melphalan as pre-transplant conditioning is safe in patients with heavily pre-treated multiple myeloma

P A Thompson, H M Prince, J F Seymour, D Ritchie, K Stokes… in Bone Marrow Transplantation (2011)

Article

Plasma and cerebrospinal fluid pharmacokinetics of MP470 in non-human primates

MP470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret that is being evaluated as an anticancer agent. The plasma and cerebrospinal fluid (...

P. A. Baxter, P. A. Thompson, L. M. McGuffey… in Cancer Chemotherapy and Pharmacology (2011)

Chapter

Breast Cancer Prevention

Early detection, combined with targeted and more effective therapies, has led to reductions in breast cancer related deaths. Approximately 90% of women diagnosed with breast cancer in the US today are disease ...

P. A. Thompson, A. T. Stopeck in Fundamentals of Cancer Prevention (2008)

Article

Derivation and Use of Sediment Quality Guidelines for Ecological Risk Assessment of Metals and Radionuclides Released to the Environment from Uranium Mining and Milling Activities in Canada

The Screening Level Concentration (SLC) approach was used to derive Lowest Effect Level (LEL) and Severe Effect Level (SEL) concentrations for nine metals (As, Cr, Cu, Pb, Mo, Ni, Se, U and V) and three radion...

P. A. Thompson, J. Kurias, S. Mihok in Environmental Monitoring and Assessment (2005)

Chapter and Conference Paper

A 14-Tesla 15-Centimeter-Bore Superconductive Magnet

Water-cooled, cryogenically cooled, and superconducting magnets of various types are currently in use at the Lewis Research Center [^1–5]. These magnets are a part of a broad program for advanced space propulsion ...

W. D. Coles, E. R. Schrader, P. A. Thompson in Advances in Cryogenic Engineering (1995)

Article

Influence of irradiance on the nutritional value of two phytoplankton species fed to larval Japanese scallops (Patinopecten yessoensis)

Japanese scallop (Patinopectin yessoensis Jay) larvae grew faster and were larger after 18 d when fed a diet of high-light(HL)-grown Chaetoceros simplex or HL Pavlova lutheri relative to diets of the same phytopl...

P. A. Thompson, M. -X. Guo, P. J. Harrison in Marine Biology (1994)

Chapter

Immunological factors that influence disease severity in experimental autoimmune myasthenia gravis

In health, acetylcholine receptors (AChR) associated with muscle membrane at the endplate are designed to capture acetylcholine molecules released from vesicles at the motor nerve terminals. The AChR, complexe...

K. A. Krolick, P. A. Thompson, T. E. Zoda, S. Mohan… in Immunology of Neuromuscular Disease (1994)

Article

The influence of irradiance on the biochemical composition of three phytoplankton species and their nutritional value for larvae of the Pacific Oyster (Crassostrea gigas)

Three species of phytoplankton grown at high (HL) or low light (LL) were fed as saturating rations to laboratory-reared larval Crassostrea gigas. Larval C. gigas fed diets of HL grown Chaetoceros gracilis and HL ...

P. A. Thompson, M. Guo, P. J. Harrison in Marine Biology (1993)

Article

Effects of light, temperature and salinity on the growth rate of harmful marine diatoms, Chaetoceros convolutus and C. concavicornis that kill netpen salmon

Chaetoceros convolutus and C. concavicornis have been implicated in the death of salmon in netpens in the Pacific Northwest by damaging the salmon's gills. To better understand how enviro...

P. J. Harrison, P. A. Thompson, M. Guo, F. J. R. Taylor in Journal of Applied Phycology (1993)

Chapter and Conference Paper

Vibrated Granular Assemblies: Fluidization and Convection

Molecular dynamics simulations of noncohesive granular assemblies under vibrations are described. The upper portion of the assembly undergoes a fluidization transition when the vibrational accelerations are su...

P. A. Thompson in Computer Simulation Studies in Condensed-Matter Physics VI (1993)

Article

A Two-Legged Spacer Molecule for Alternate Layer LB Film Deposition with Optically Nonlinear Dyes

Second harmonic generation from Langmuir-Blodgett films of E-N-octadecyl-4-(2-(4-dimethylaminophenyl)ethenyl)pyridinium iodide (a hemicyanine) interleaved with 4, 4’-dioctadecyl-3, 5, 3’, 5’-tetramethyldipyrry...

G. J. Ash Well, W. A. Crossland, P. J. Martin… in MRS Online Proceedings Library (1992)

Chapter

Limits to Microalgal Growth

Our objectives were to determine: 1) the influence of different N forms (NH₄ ⁺, NO₃, and urea) on the growth rate and on the nitrogen and carbon content of four microalgae, and 2) to relate the N ...

M. Levasseur, P. A. Thompson, P. J. Harrison in Primary Productivity and Biogeochemical Cy… (1992)