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Article
Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway
Ibrutinib, a covalent inhibitor of Bruton Tyrosine Kinase (BTK), is approved for treatment of patients with relapsed/refractory or treatment-naïve chronic lymphocytic leukemia (CLL). Besides directly inhibitin...
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Article
Open AccessATM function and its relationship with ATM gene mutations in chronic lymphocytic leukemia with the recurrent deletion (11q22.3-23.2)
Approximately 10–20% of chronic lymphocytic leukemia (CLL) patients exhibit del(11q22–23) before treatment, this cohort increases to over 40% upon progression following chemoimmunotherapy. The coding sequence ...
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Article
Water based nanofluids for automotive applications
This paper presents a recent work on enhanced heat transfer properties of carboxylated water based nanofluids and their corrosive behavior for suitability to automotive conditions. Water mixed with Sebacic aci...
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Article
Umbilical cord blood graft engineering: challenges and opportunities
We are entering a very exciting era in umbilical cord blood transplantation (UCBT), where many of the associated formidable challenges may become treatable by ex vivo graft manipulation and/or adoptive immunother...
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Article
A comparison of the direct cost of care in an open-bay and single-family room NICU
This research examined the proposition that the direct costs of care were no different in an open-bay (OPBY) as compared with a single-family room (SFR) neonatal intensive care (NICU) environment.
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Article
Open AccessA reanalysis of cancer mortality in Canadian nuclear workers (1956–1994) based on revised exposure and cohort data
A 15-country study of nuclear workers reported significantly increased radiation-related risks of all cancers excluding leukaemia, with Canadian data a major factor behind the pooled results. We analysed morta...
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Article
Primary production and phytoplankton community structure during a winter shelf-scale phytoplankton bloom off Western Australia
Regions of high primary production along the oligotrophic west coast of Australia between 34 and 22°S in May–June 2007 (midway through the annual phytoplankton bloom) were found around mesoscale features of th...
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Article
Bortezomib added to high-dose melphalan as pre-transplant conditioning is safe in patients with heavily pre-treated multiple myeloma
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Article
Plasma and cerebrospinal fluid pharmacokinetics of MP470 in non-human primates
MP470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret that is being evaluated as an anticancer agent. The plasma and cerebrospinal fluid (...
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Chapter
Breast Cancer Prevention
Early detection, combined with targeted and more effective therapies, has led to reductions in breast cancer related deaths. Approximately 90% of women diagnosed with breast cancer in the US today are disease ...
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Article
Derivation and Use of Sediment Quality Guidelines for Ecological Risk Assessment of Metals and Radionuclides Released to the Environment from Uranium Mining and Milling Activities in Canada
The Screening Level Concentration (SLC) approach was used to derive Lowest Effect Level (LEL) and Severe Effect Level (SEL) concentrations for nine metals (As, Cr, Cu, Pb, Mo, Ni, Se, U and V) and three radion...
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Article
Lymphoid Hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD→NOD-scid adoptive T cell transfer
Sustained antibody-mediated inhibition of tumor necrosis factor (TNF) activity offers protection against Type I (insulin-dependent) diabetes mellitus in non-obese diabetic (NOD) mice. The mechanism of this ef...
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Chapter and Conference Paper
A 14-Tesla 15-Centimeter-Bore Superconductive Magnet
Water-cooled, cryogenically cooled, and superconducting magnets of various types are currently in use at the Lewis Research Center [1–5]. These magnets are a part of a broad program for advanced space propulsion ...
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Article
Influence of irradiance on the nutritional value of two phytoplankton species fed to larval Japanese scallops (Patinopecten yessoensis)
Japanese scallop (Patinopectin yessoensis Jay) larvae grew faster and were larger after 18 d when fed a diet of high-light(HL)-grown Chaetoceros simplex or HL Pavlova lutheri relative to diets of the same phytopl...
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Chapter
Immunological factors that influence disease severity in experimental autoimmune myasthenia gravis
In health, acetylcholine receptors (AChR) associated with muscle membrane at the endplate are designed to capture acetylcholine molecules released from vesicles at the motor nerve terminals. The AChR, complexe...
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Article
The influence of irradiance on the biochemical composition of three phytoplankton species and their nutritional value for larvae of the Pacific Oyster (Crassostrea gigas)
Three species of phytoplankton grown at high (HL) or low light (LL) were fed as saturating rations to laboratory-reared larval Crassostrea gigas. Larval C. gigas fed diets of HL grown Chaetoceros gracilis and HL ...
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Article
Effects of light, temperature and salinity on the growth rate of harmful marine diatoms, Chaetoceros convolutus and C. concavicornis that kill netpen salmon
Chaetoceros convolutus and C. concavicornis have been implicated in the death of salmon in netpens in the Pacific Northwest by damaging the salmon's gills. To better understand how enviro...
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Chapter and Conference Paper
Vibrated Granular Assemblies: Fluidization and Convection
Molecular dynamics simulations of noncohesive granular assemblies under vibrations are described. The upper portion of the assembly undergoes a fluidization transition when the vibrational accelerations are su...
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Article
A Two-Legged Spacer Molecule for Alternate Layer LB Film Deposition with Optically Nonlinear Dyes
Second harmonic generation from Langmuir-Blodgett films of E-N-octadecyl-4-(2-(4-dimethylaminophenyl)ethenyl)pyridinium iodide (a hemicyanine) interleaved with 4, 4’-dioctadecyl-3, 5, 3’, 5’-tetramethyldipyrry...
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Chapter
Limits to Microalgal Growth
Our objectives were to determine: 1) the influence of different N forms (NH4 +, NO3, and urea) on the growth rate and on the nitrogen and carbon content of four microalgae, and 2) to relate the N ...