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Article
Open AccessReal-world evidence of ocrelizumab-treated relapsing multiple sclerosis cohort shows changes in progression independent of relapse activity mirroring phase 3 trials
Ocrelizumab is a B cell-depleting drug widely used in relapsing–remitting multiple sclerosis (RRMS) and primary-progressive MS. In RRMS, it is becoming increasingly apparent that accumulation of disability not...
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Article
Open AccessPro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile
Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-infla...
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Article
Asylbewerber und ihre Versorgungssituation
Die medizinische Versorgung von geflüchteten Menschen ist in Deutschland gesetzlich stark reguliert. Die regional sehr unterschiedliche Umsetzung stellt derzeit aber eine große Herausforderung dar. Die spezifi...
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Article
BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival
The endoplasmic reticulum (ER) serves as the major intracellular Ca2+ store and has a role in the synthesis and folding of proteins. BAX (BCL2-associated X protein) inhibitor-1 (BI-1) is a Ca2+ leak channel also ...
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Chapter
Gastroesophageal Reflux Disease in Children with Interstitial Lung Disease
Gastroesophageal reflux disease is common in adult patients with interstitial lung disease. However, no data currently exist regarding the prevalence and characteristics of the disease in pediatric patients wi...
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Article
Open AccessControlling a VRE cluster on a surgical ward
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Chapter and Conference Paper
Evaluation of Laryngopharyngeal Reflux in Pediatric Patients with Asthma Using a New Technique of Pharyngeal pH-Monitoring
There is a debate about the association between asthma and gastroesophageal and/or laryngopharyngeal reflux (LPR). Pharyngeal pH-monitoring is a new technique that allows a physician to assess whether reflux p...
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Article
Open AccessThe plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress
The mouse hippocampal cell line HT22 is an excellent model for studying the consequences of endogenous oxidative stress. Addition of extracellular glutamate depletes the cells of glutathione (GSH) by blocking ...
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Article
Indirect population impact of universal PCV7 vaccination of children in a 2 + 1 schedule on the incidence of pneumonia morbidity in Kielce, Poland
The aim of this study was an analysis of the population effects of a seven-valent pneumococcal conjugate vaccine (PCV7) on pneumonia incidence rates in the 5-year follow-up period after the introduction in 200...
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Article
Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression
Selecting neuronal cell lines for resistance against oxidative stress might recapitulate some adaptive processes in neurodegenerative diseases where oxidative stress is involved like Parkinson's disease. We re...
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Article
POEMS-Syndrom
Das POEMS-Syndrom ist eine seltene paraneoplastische Erkrankung, die mit einer Polyneuropathie, Organomegalie, Endokrinopathie, monoklonalen Plasmazellerkrankung und Haut („Skin“)-Veränderungen einhergeht. Erhöht...
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Article
Significant decline in pneumonia admission rate after the introduction of routine 2+1 dose schedule heptavalent pneumococcal conjugate vaccine (PCV7) in children under 5 years of age in Kielce, Poland
This study was performed to estimate the effect of heptavalent pneumococcal conjugate vaccine (PCV7) on the pneumonia admission rate in children younger than 5 years of age, after the introduction of routine 2...
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Article
Open AccessFree caspase activity in CSF of patients with dementia
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Article
Invasive pneumococcal disease in children up to 5 years of age in Poland
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Article
Optical coherence tomography measures axonal loss in multiple sclerosis independently of optic neuritis
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Chapter and Conference Paper
NACA0012 wing with rounded tip
This chapter describes the common effort of UMIST, EADS-CASA, ALENIA and TUB to compute the steady vortex evolving at the round tip of a wing at 10° angle of attack. Results for different numerical grids obtai...
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Article
Temperature-Induced Change of Variant Surface Antigen Expression in ParameciumInvolves Antigen Release into the Culture Medium with Considerable Delay betweenTranscription and Surface Expression
We analyzed temperature-induced changes of variant surface antigen (vsAg) expression in Paramecium primaurelia, using immuno-techniques and mRNA determinations. Upon a 23°C to 33°C shift, the old vsAg, type 156G,...
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Article
Analysis of optical crosstalk within optoelectronic integrated circuits including lasers and photodetectors
Optical crosstalk from a 1.3 μm laser to a 1.55 μm photodiode on a single InP substrate, and its suppression within 1.3 μm/1.5 μm Y-junction transceiver OEICs, has been analyzed experimentally. The results ind...
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Article
Extraction of bound porphyrins from sulphur-rich sediments and their use for reconstruction of palaeoenvironments
PORPHYRINS, which are present in most sediments and crude oils, represent the 'molecular fossils' of compounds such as chlorophylls, bacteriochlorophylls and haems in the organisms from which the organic mater...
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Article
Structural evidence for heme fossils in Messel oil shale (FRG)