13 Result(s)
within
Osamu Ogawa
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessEffects of thienopyridine class antiplatelets on bleeding outcomes following robot-assisted radical prostatectomy
This study aimed to assess the effects of thienopyridine-class antiplatelet agents (including ticlopidine, clopidogrel, and prasugrel) on bleeding complications in patients who underwent robot-assisted radical...
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Open AccessRisk analyses of nocturia on incident poor sleep and vice versa: the Nagahama study
Cross-sectional relationships between nocturia and sleep problems have been well evaluated but the risk association for each incidence is scarcely reported. This analysis included 8076 participants of the Naga...
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Article
Open AccesseVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA
Plasma cell-free DNA (cfDNA) testing plays an increasingly important role in precision medicine for cancer. However, circulating cell-free tumor DNA (ctDNA) is highly diluted by cfDNA from non-cancer cells, co...
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Article
Open Access12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population
Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were identified in European populations. We here performed a GWAS and repli...
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Article
Open AccessAnalytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma
Current clinically approved biomarkers for the PD-1 blockade cancer immunotherapy are based entirely on the properties of tumour cells. With increasing awareness of clinical responses, more precise biomarkers ...
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Article
Open AccessClinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancer
The therapeutic landscape of castration-resistant prostate cancer (CRPC) has rapidly expanded. There is a need to develop noninvasive biomarkers to guide treatment. We established a highly sensitive method for...
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Article
Open AccessCircadian coordination of ATP release in the urothelium via connexin43 hemichannels
Day-night changes in the storage capacity of the urinary bladder are indispensable for sound sleep. Connexin 43 (Cx43), a major gap junction protein, forms hemichannels as a pathway of ATP in other cell types,...
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Article
Open AccessAuthentic role of ATP signaling in micturition reflex
Adenosine triphosphate (ATP) is a signaling molecule that regulates cellular processes. Based on previous studies of bladder function over the past decade, bladder ATP signaling was thought to have an essentia...
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Article
Open AccessCXCL1 is elevated in the urine of bladder cancer patients
Chemokines, including chemokine (C-X-C motif) ligand 1 (CXCL1), regulate tumor epithelial-stromal interactions that facilitate tumor growth and invasion. Recently, several studies have linked CXCL1 expression ...
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Article
Open AccessPannexin 1 involvement in bladder dysfunction in a multiple sclerosis model
Bladder dysfunction is common in Multiple Sclerosis (MS) but little is known of its pathophysiology. We show that mice with experimental autoimmune encephalomyelitis (EAE), a MS model, have micturition dysfunc...
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Article
Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm
Nocturnal enuresis in children and nocturia in the elderly are two highly prevalent clinical conditions characterized by a mismatch between urine production rate in the kidneys and storage in the urinary bladd...
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Article
Open AccessBALB/c-Fcgr2b−/−Pdcd1−/− mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis
We report the impact of anti-urothelial autoantibody (AUAb) on urinary bladder phenotype in BALB/c mice deficient of the FcγRIIb and PD-1. AUAb was present in serum samples from approximately half of the doubl...
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Article
Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
GENOMIC imprinting has been implicated in the onset of several embryonal tumours but the mechanism is not well understood1–3. Maternal chromosome 11p15 loss of heterozygosity4 and paternal chromosome 11 isodisomy
