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Open AccessRisk analyses of nocturia on incident poor sleep and vice versa: the Nagahama study
Cross-sectional relationships between nocturia and sleep problems have been well evaluated but the risk association for each incidence is scarcely reported. This analysis included 8076 participants of the Naga...
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Article
Open AccessGenomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in...
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Cohort Profile: The Nagahama Prospective Genome Cohort for Comprehensive Human Bioscience (The Nagahama Study)
The Nagahama Prospective Cohort for Comprehensive Human Bioscience is the first large-scale multipurpose genome cohort in Japan. The project started in 2007 with a new concept of “pre-primary prevention” aimin...
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Socio-Life Scientific Survey on COVID-19
In overcoming the COVID-19 crisis, contribution from social science is indispensable as well as medical research. With this consideration, we have initiated a socio-life scientific survey on COVID-19, which is...
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Article
Open AccessAssociation between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study
Circulating levels of inflammatory proteins have to be prognostic markers of all-cause mortality. α1-Antitrypsin (AAT) is a major inflammatory plasma protein, but its association with all-cause mortality is un...
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Article
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregate...
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Article
Open AccessProtocol for development and validation of a prediction model for 5-year risk of incident overactive bladder in the general population: the Nagahama study
An accurate prediction model could identify high-risk subjects of incident Overactive bladder (OAB) among the general population and enable early prevention which may save on the related medical costs. However...
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Article
Open AccessCerebral small vessel disease genomics and its implications across the lifespan
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WM...
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Article
Frequent nocturnal urination in older men is associated with arterial stiffness: The Nagahama study
Nocturia in older adults has been reported to be a risk factor for cardiovascular outcomes, and the stiffening of large arteries might be an underlying mechanism. To clarify the possible association between no...
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Article
Association of the spot urine sodium-to-potassium ratio with blood pressure is independent of urinary Na and K levels: The Nagahama study
The sodium-to-potassium ratio (Na/K) of a urine sample is a simple index of salt loading. To practically use Na/K, we aimed to determine whether the Na/K value affects blood pressure (BP) at any age, irrespect...
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Open AccessLow back pain precedes the development of new knee pain in the elderly population; a novel predictive score from a longitudinal cohort study
To investigate the association between knee pain and risk factors including low back pain and to develop a score to predict new knee pain in an older population, using population-based longitudinal cohort data.
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Association between socioeconomic factors and urinary sodium-to-potassium ratio: the Nagahama Study
High sodium intake is a simple modifiable risk factor for hypertension. Although not confirmed, lower socioeconomic status may be a factor that increases sodium intake. We aimed to clarify the association betw...
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Clinical significance of an elevated ankle-brachial index differs depending on the amount of appendicular muscle mass: the J-SHIPP and Nagahama studies
Clinical implication of a high ankle-brachial index (ABI) is not well known. Based on our previous study, we suspected that body composition may be a determinant of a high ABI and may consequently modulate the...
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Open AccessThree missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels
Alpha-1 antitrypsin (AAT) encoded by SERPINA1 is an acute-phase inflammation marker, and AAT deficiency (AATD) is known as one of the common genetic disorders in European populations. However, no genetic determin...
