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Article
Open AccessStochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes
Mutations of several genes cause incomplete penetrance and variable expressivity of phenotypes, which are usually attributed to modifier genes or gene-environment interactions. Here, we show stochastic gene ex...
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Article
Periodic inhibition of Erk activity drives sequential somite segmentation
Sequential segmentation creates modular body plans of diverse metazoan embryos1–4. Somitogenesis establishes the segmental pattern of the vertebrate body axis. A molecular segmentation clock in the presomitic mes...
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Article
Pairing of segmentation clock genes drives robust pattern formation
Gene expression is an inherently stochastic process1,2; however, organismal development and homeostasis require cells to coordinate the spatiotemporal expression of large sets of genes. In metazoans, pairs of co-...