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Article
Open AccessCorrection: Enabling direct microcalorimetric measurement of metabolic activity and exothermic reactions onto microfluidic platforms via heat flux sensor integration
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Article
Open AccessAntimicrobial and mechanical assessment of cellulose-based thermoformable material for invisible dental braces with natural essential oils protecting from biofilm formation
Controlling biofilm formation in the oral cavity during orthodontic treatments is crucial. Therefore, antimicrobial surfaces for invisible dental appliances are of interest to both therapists and patients. Her...
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Article
Open AccessNeurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset
Chronic liver disease (CLD) is a serious condition where various toxins present in the blood affect the brain leading to type C hepatic encephalopathy (HE). Both adults and children are impacted, while childre...
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Article
Open AccessEnabling direct microcalorimetric measurement of metabolic activity and exothermic reactions onto microfluidic platforms via heat flux sensor integration
All biological processes use or produce heat. Traditional microcalorimeters have been utilized to study the metabolic heat output of living organisms and heat production of exothermic chemical processes. Curre...
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Article
Use of isothermal microcalorimetry to characterize the behavior of the microencapsulated biocontrol agent Meyerozyma guilliermondii
The effect of the microencapsulation by spray drying of the biocontrol agent Meyerozyma guilliermondii was evaluated by isothermal microcalorimetry (IMC) and traditional microbiological methods. The concentration...
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Chapter
Disorders of Creatine Metabolism
Reduced creatine levels in the brain and in body fluids/tissues are the common denominator of primary creatine disorders (cerebral creatine deficiency syndromes types 1–3: X-linked creatine transporter (CrT/SLC6A...
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Article
Open AccessProbiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE
Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiot...
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Article
Open AccessProbiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternati...
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Article
Open AccessA new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism
Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high energy demand such as muscle or brain. Creatine is taken from the diet or endogenously synthe...
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Article
Open AccessEffect of divalent ions on cariogenic biofilm formation
Divalent cations are able to interact with exopolysaccharides (EPS) and thus are capable to modify the structure and composition of dental biofilm. At the moment, little is known about the adsorption of metals...
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Article
Open AccessLongitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease
Type C hepatic encephalopathy (type C HE) is increasingly suspected in children with chronic liver disease (CLD), and believed to underlie long-term neurocognitive difficulties. The molecular underpinnings of ...
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Protocol
Measuring the Metabolic Activity of Mature Mycobacterial Biofilms Using Isothermal Microcalorimetry
Measuring metabolic activity and response of biofilm to different conditions or compounds is of general interest but is also expected to help in develo** new antibiofilm compounds and potentially new treatme...
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Article
Open AccessMetabolic activity of mature biofilms of Mycobacterium tuberculosis and other non-tuberculous mycobacteria
Mycobacteria are classified into two groups, fast- and slow-growing. Often, fast-growing mycobacteria are assumed to have a higher metabolic activity than their slower counterparts, but in mature biofilms this...
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Article
1H and 31P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism
Chronic liver disease (CLD) leads to a spectrum of neuropsychiatric disorders named hepatic encephalopathy (HE). Even though brain energy metabolism is believed to be altered in chronic HE, few studies have ex...
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Article
Creatine synthesis and exchanges between brain cells: What can be learned from human creatine deficiencies and various experimental models?
While it has long been thought that most of cerebral creatine is of peripheral origin, the last 20 years has provided evidence that the creatine synthetic pathway (AGAT and GAMT enzymes) is expressed in the br...
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Article
Open AccessComparison of Tunable Diode Laser Absorption Spectroscopy and Isothermal Micro-calorimetry for Non-invasive Detection of Microbial Growth in Media Fills
Two methods were investigated for non-invasive microbial growth-detection in intact glass vials as possible techniques for automated inspection of media-filled units. Tunable diode laser absorption spectroscop...
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Article
A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus
Soil-transmitted helminths, which affect the poorest communities, worldwide cause a range of symptoms and morbidity, yet few treatment options are available and drug resistance is a concern. To improve and acc...
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Article
Isolation and characterization of oxalotrophic bacteria from tropical soils
The oxalate–carbonate pathway (OCP) is a biogeochemical set of reactions that involves the conversion of atmospheric CO2 fixed by plants into biomass and, after the biological recycling of calcium oxalate by fung...
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Chapter
Creatine Disorders
Reduced creatine levels in the brain and in body fluids/tissues are the common denominator of primary (AGAT, GAMT, X-linked creatine transporter (SLC6A8) deficiency) and secondary (OAT deficiency) creatine disord...
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Article
Ammonia toxicity to the brain
Hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle defects. The brain is much more susceptible to the deleterious effects of ammonium in childhood than in adulthood. Hyp...
