Peptide and Protein Engineering
From Concepts to Biotechnological Applications
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Protocol
Integration of Molecular Dynamics Based Predictions into the Optimization of De Novo Protein Designs: Limitations and Benefits
Recent advances in de novo protein design have gained considerable insight from the intrinsic dynamics of proteins, based on the integration of molecular dynamics simulations protocols on the state-of-the-art ...
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Article
Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles
Our objective was to determine the lowest diagnostically effective dose for E-selectin-targeted poly n-butyl cyanoacrylate (PBCA)-shelled microbubbles and to apply it to monitor antiangiogenic therapy effects.
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Article
Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons
The identification of an enzymatic system repairing proteins containing oxidized methionine in the bacterial cell envelope, a compartment particularly susceptible to oxidative damage by host defence mechanisms.
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Article
Recruitment of divalent metal ions by incorporation of 4-thio-2′-deoxythymidine or 4-thio-2′-deoxyuridine into DNA
The modified nucleosides 4-thio-2′-deoxyuridine (s4dU) and 4-thio-2′-deoxythymidine (s4dT) are incorporated into dinucleosides, and s4dT is incorporated into a DNA hairpin loop to provide divalent metal ion bindi...
