-
Article
Open AccessA possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet’s disease
Behcet’s disease (BD) is a multisystem disease with altered Toll-like receptors (TLRs) on macrophages. Long noncoding RNA Maternally expressed gene 3 (lncRNA MEG3) and lncRNA Musculoaponeurotic fibrosarcoma on...
-
Article
Open AccessAssociation between bone turnover markers, bone mineral density, and serum osteoglycine in middle-aged men with Type 2 Diabetes mellitus
Patients with Type 2 diabetes mellitus (T2DM) have decreased bone health. We aimed to investigate serum levels of bone turnover markers (BTMs) (markers of bone formation and bone resorption) and bone mineral d...
-
Article
Open AccessMelatonin and mesenchymal stem cells co-administration alleviates chronic obstructive pulmonary disease via modulation of angiogenesis at the vascular-alveolar unit
Chronic obstructive pulmonary disease (COPD) is considered a severe disease mitigating lung physiological functions with high mortality outcomes, insufficient therapy, and pathophysiology pathways which is sti...
-
Article
Open AccessSerum ACE2 and S19P gene polymorphism in Egyptian patients with COVID-19 infection: correlation with disease severity
The expression of ACE2 is linked to disease severity in COVID-19 patients. The ACE2 receptor gene polymorphisms are considered determinants for SARS-CoV-2 infection and its outcome. In our study, serum ACE2 an...
-
Article
Open AccessClinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial
Oral lichen planus (OLP) is a chronic mucocutaneous immunologically mediated condition that has a great adverse effect on oral functions. Corticosteroids are still the first drugs of choice used in the treatme...
-
Article
Open AccessLocal gingival crevicular fluid, synovial fluid, and circulating levels of prolactin hormone in patients with moderately active rheumatoid arthritis and stage III and IV periodontitis before and after non-surgical periodontal treatment—a controlled trial
We aimed to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF), synovial fluid, and serum in patients suffering from moderately active rheumatoid arthritis (RA) with and without periodontiti...
-
Article
Open AccessInvestigation of association of biomarkers of iron metabolism and insulin resistance in Egyptian patients with impaired glucose metabolism and type 2 diabetes
Type 2 diabetes is an expanding overall medical issue. A large portion of the enthusiasm for the job of supplements in diabetes is fixated on macronutrients, yet a micronutrient, iron, is additionally closely ...
-
Article
Open AccessIFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis
Fibrosis across different organs and tissues is likely to share common pathophysiological mechanisms and pathways. Recently, a polymorphism (rs12979860) near the interferon lambda gene (IFNL3) was shown to be ass...
-
Article
Possible use of miRNAs-146a and -499 expression and their polymorphisms as diagnostic markers for rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disorder affecting the peripheral joints. Different microRNAs had been investigated in RA including miRNA-146a meanwhile, miRNA-499 there were no studies to p...
-
Chapter and Conference Paper
Classification of Liver Fibrosis Patients by Multi-dimensional Analysis and SVM Classifier: An Egyptian Case Study
One of the most critical concerns in different fields, particularly in the medical domain, is the time taken to arrive at a decision. In Egypt, Liver fibrosis is one of the medical conditions affecting a large...
-
Article
B cell activating factor and T-helper 17 cells: possible synergistic culprits in the pathogenesis of Alopecia Areata
The role of T-helper 17 cells (Th17) and regulatory T-cells (Tregs) in the pathogenesis of alopecia areata (AA) has not been clearly elucidated. B cell activating factor (BAFF) being a regulator of T cell acti...
-
Article
Open AccessInterferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as...
-
Chapter and Conference Paper
Case-Based Reasoning: A Knowledge Extraction Tool to Use
Case-based reasoning (CBR) is a relative newcomer to AI and is commonly described as an AI as well as KM technology. Case-Based Reasoning is considered as a methodology not a technology to use. Finding the sim...
-
Chapter and Conference Paper
Distance Similarity as a CBR Technique for Early Detection of Breast Cancer: An Egyptian Case Study
Case-based reasoning as a concept covers almost a lot of technologies and techniques including knowledge management, artificial intelligence, machine learning techniques as well as database technology. The usa...
-
Article
Is rs8099917 Polymorphism of IL-28B Gene a Good Predictor of Response to Therapy of HCV than rs12979860? An Egyptian Study
Hepatitis C virus (HCV) infection is the major etiology of chronic liver disease. Polymorphisms in the IL-28B gene region are important in predicting outcome following therapy for chronic hepatitis C virus in...
-
Article
Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience
Patients with thalassemia major requiring regular blood transfusions accumulate iron that is toxic to the heart, liver, and endocrine systems. The following prospective, randomized trial was carried out to det...
