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Article
Primary Cilia-Mediated Osteogenic Response to Fluid Flow Occurs via Increases in Focal Adhesion and Akt Signaling Pathway in MC3T3-E1 Osteoblastic Cells
Fluid flow is an important anabolic mechanical signal that results in the upregulation of osteogenic responses in bone cells. Primary cilium may be responsible for the sensing of mechanical signals and convert...
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Article
Quantification of temporal changes in 3D osteoclastic resorption pit using confocal laser scanning microscopy
Osteoclasts, cells responsible for bone resorption, generate 3D resorption pits by attaching to the bone surface and excavating the underneath bone matrix. Changes in trabecular bone microstructure due to thes...
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Article
Open AccessPlasma dilution improves cognition and attenuates neuroinflammation in old mice
Our recent study has established that young blood factors are not causal, nor necessary, for the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral blood exchange (NBE) tha...
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Article
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phen...