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Article
Open AccessDapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling
Recent studies have reported improved diastolic function in patients administered sodium-glucose cotransporter 2 inhibitors (SGLT2i). We aimed to investigate the effect of dapagliflozin on left ventricular (LV...
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Article
Systemic induction of senescence in young mice after single heterochronic blood exchange
Ageing is the largest risk factor for many chronic diseases. Studies of heterochronic parabiosis, substantiated by blood exchange and old plasma dilution, show that old-age-related factors are systemically pro...
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Article
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phen...
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Article
Open AccessPlasma dilution improves cognition and attenuates neuroinflammation in old mice
Our recent study has established that young blood factors are not causal, nor necessary, for the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral blood exchange (NBE) tha...
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Article
Open AccessSequential dual-drug delivery of BMP-2 and alendronate from hydroxyapatite-collagen scaffolds for enhanced bone regeneration
The clinical use of bioactive molecules in bone regeneration has been known to have side effects, which result from uncontrolled and supraphysiological doses. In this study, we demonstrated the synergistic eff...
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Article
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Pharmacological or genetic depletion of senescent cells in the joint ameliorates osteoarthritis in mice.
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Article
Open AccessHuman iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials
Bone substitutes can be designed to replicate physiological structure and function by creating a microenvironment that supports crosstalk between bone and immune cells found in the native tissue, specifically ...
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Article
Orthopedic tissue regeneration: cells, scaffolds, and small molecules
Orthopedic tissue regeneration would benefit the aging population or patients with degenerative bone and cartilage diseases, especially osteoporosis and osteoarthritis. Despite progress in surgical and pharmac...
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Article
Quantification of temporal changes in 3D osteoclastic resorption pit using confocal laser scanning microscopy
Osteoclasts, cells responsible for bone resorption, generate 3D resorption pits by attaching to the bone surface and excavating the underneath bone matrix. Changes in trabecular bone microstructure due to thes...
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Article
Primary Cilia-Mediated Osteogenic Response to Fluid Flow Occurs via Increases in Focal Adhesion and Akt Signaling Pathway in MC3T3-E1 Osteoblastic Cells
Fluid flow is an important anabolic mechanical signal that results in the upregulation of osteogenic responses in bone cells. Primary cilium may be responsible for the sensing of mechanical signals and convert...
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Article
The Abnormal Regulation of Gene Expression in Autistic Brain Tissue
Autism is a pervasive developmental disorder of unknown etiology. It is likely caused by mutations in one or more genes. One approach to understanding the molecular changes that occur in autism is to measure g...
