146 Result(s)

Article

Synthesis and structure of Schiff bases derived from 3-formyl-4-hydroxycoumarin and diamines

The mono- and diimine products from the condensation of 3-formyl-4-hydroxycoumarin and various diamines were synthesized. It was shown by ¹H NMR and mass spectrometry that the obtained compounds in DMSO-d₆ soluti...

B. G. Milevskii, T. A. Chibisova, N. P. Solov’eva… in Chemistry of Heterocyclic Compounds (2013)

Article

Transformations of coumarins accompanied by intermediate opening and recyclization of the lactone ring 3.* Study of the reactions of 3-ethoxy-carbonylcoumarins with cyanoacetyl-hydrazines by NMR spectroscopy

The reaction of 3-ethoxycarbonylcoumarin with derivatives of cyanoacetylhydrazine directly in the sample tube of the NMR spectrometer was investigated by ¹H NMR spectroscopy. The structure of the components of th...

N. P. Solov’eva, V. D. Dimitrova, M. P. Nemeryuk… in Chemistry of Heterocyclic Compounds (2010)

Article

New synthesis of pyrido[4,3-b]indoles (γ-carbolines) on the basis of indolin-2-one lactim ether

Condensation of indolin-2-one (oxindole) lactim ether with malononitrile leads to 2-dicyanomethylidene-2,3-dihydroindole, the reaction of which with dimethylformamide diethyl acetal (or with triethyl orthoform...

T. V. Golovko, N. P. Solov’eva, O. S. Anisimova… in Russian Chemical Bulletin (2008)

Article

Synthesis, properties, and reactions of derivatives of 1,3-dimethyl-6-(5′-aminopyrimidylthio-6′)uracils

Derivatives of 1,3-dimethyl-6-(5′-aminopyrimidylthio-6′)uracils were synthesized and some of their properties and reactions were studied.

T. S. Safonova, M. P. Nemeryuk, M. M. Likhovidova… in Pharmaceutical Chemistry Journal (2008)

Article

Develo** analytical methods for the creation of the state reference sample of noopept

The physicochemical properties of noopept, a new domestic original drug with nootropic action, have been studied with a view to develo** analytical methods, establishing quality criteria for the parent drug ...

A. V. Gusev, L. N. Grushevskaya, O. B. Stepanenko… in Pharmaceutical Chemistry Journal (2007)

Article

New synthesis of benzo[b][1,6]naphthyridines and pyrido[4,3-b]benz[f]azepines from lactim ethers of 3,4-dihydrocarbostyril and 1H-2,3,4,5-tetrahydrobenz[b]azepin-2-one

Condensation of lactim ethers of 3,4-dihydrocarbostyril and 1H-2,3,4,5-tetrahydrobenz[b]azepin-2-one with malonodinitrile, cyanoacetamide, and ethyl cyanoacetate gave the corresponding 2-methylidene derivatives. ...

T. V. Golovko, O. B. Smirnova, N. P. Solov’eva… in Russian Chemical Bulletin (2007)

Article

Sesquiterpene lactones in juice of great burdock leaves

The chemical composition of the juice of freshly collected great burdock (Arctium Lappa L.) leaves was studied. The main components in the ethyl acetate extract were determined. Adifference between the samples co...

A. A. Savina, V. I. Sheichenko, Yu. V. Stikhin… in Pharmaceutical Chemistry Journal (2006)

Article

Heterocyclic analogs of 5,12-naphthacenequinone. 2. Synthesis of 4,11-dihydroxynaphtho[2,3-f]indazole-5,10-dione and its n-methyl derivatives

On methylating 4,11-dimethoxynaphtho[2,3-f]indazole-5,10-dione with methyl iodide in the presence of base a mixture is formed of its 1-and 2-methyl derivatives. Demethylation of the methoxy groups of the start...

A. E. Shchekotikhin, Yu. N. Luzikov, O. S. Anisimova… in Chemistry of Heterocyclic Compounds (2006)

Article

Conversions of Coumarins Accompanied by Intermediate Opening and Recyclization of the Lactone Ring. 2. Study of the Interaction of Malonic Acid Hydrazide and Amide Derivatives with 3-Acyl(3-cyano, 3-ethoxycarbonyl)Coumarins

Reaction between the N,N′-diisopropylidene and N,N′-diacetyl derivatives of malonic acid dihydrazide and 3-acyl(3-cyano, 3-ethoxycarbonyl)coumarins under the conditions of the Michael reaction lead to the form...

M. P. Nemeryuk, V. D. Dimitrova, O. S. Anisimova… in Chemistry of Heterocyclic Compounds (2005)

Article

Study of Nitrogen- and Sulfur-Containing Heterocycles. 57. Synthesis and Conversion of 4′-Substituted 5-(5-Amino-6-Pyrimidylthio)-2,2-Dimethyl-4,6-Dioxo-1,3-Dioxanes

By reaction of 4-substituted 5-amino-6-mercaptopyrimidines with 5-bromo-2,2-dimethyl-4,6-dioxo-1,3-dioxane, we have obtained 4′-substituted 5-(5-amino-6-pyrimidylthio)-2,2-dimethyl-4,6-dioxo-1,3-dioxanes. We h...

T. S. Safonova, M. P. Nemeryuk, M. M. Likhovidova… in Chemistry of Heterocyclic Compounds (2005)

Article

Identification and Analysis of γ-Aminobutyric Acid in Culture Media of Producing Strains

A new modification of the accq-tag-HPLC technique for the rapid determination of L-proline and γ-aminobutyric acid (GABA) in a culture medium is proposed. The concentration of L-isoleucine added to the culture me...

A. E. Novikova, O. S. Anisimova, K. F. Turchin… in Pharmaceutical Chemistry Journal (2005)

Article

Study of nitrogen- and sulfur-containing heterocycles. 54. Properties and conversions of pyrimido[4,5-b]-1,4-benzothiazepines. Synthesis of a novel heterocyclic system: Pyrimido[5,4-c]isoquinoline

We have studied some properties and conversions of pyrimido[4,5-b]-1,4-benzothiazepines: reduction, oxidation, reactions with nucleophilic reagents (methanol, hydrazine, hydroxylamine, o-methylhydroxylamine, a...

T. S. Safonova, M. P. Nemeryuk, N. A. Grineva… in Chemistry of Heterocyclic Compounds (2004)

Article

Conversion of Coumarins Accompanied by Opening and Recyclization of the Lactone Ring. 1. Study of the Reaction of 3-Ethoxycarbonyl(3-acyl)coumarins with Cyanoacetylhydrazine and Its Derivatives

A stepwise sequence for the interaction of 3-ethoxycarbonyl(acyl)coumarins with cyanoacetylhydrazine, its N-acetyl and N-isopropylidene derivatives, leading to the formation of 3-cyanocoumarins, is proposed an...

M. P. Nemeryuk, V. D. Dimitrova, O. S. Anisimova… in Chemistry of Heterocyclic Compounds (2003)

Article

Synthesis and Biological Properties of Arylthio-1,2,3-Triazole Derivatives

T. S. Safonova, M. P. Nemeryuk, M. M. Likhovidova… in Pharmaceutical Chemistry Journal (2003)

Article

Synthesis and Study of Lactim Ethers of 3,4-Dihydrocarbostyryl and 2,3,4,5-Tetrahydrobenz[b]azepin-2-one

Alkylation of 3,4-dihydrocarbostyryl and 2,3,4,5-tetrahydrobenz[b]azepin-2-one using dimethyl sulfate and triethyloxonium fluoborate gives the corresponding lactim ethers. The reactions of lactim ethers with diff...

T. V. Golovko, N. P. Solov'eva, O. S. Anisimova… in Chemistry of Heterocyclic Compounds (2003)

Article

New Approach to the Synthesis of 3-Arylcoumarins. Reaction of 3-Acyl- and 3-Ethoxycarbonylcoumarins with Hydrazide of p-Nitrophenylacetic Acid

M. P. Nemeryuk, V. D. Dimitrova, A. L. Sedov… in Chemistry of Heterocyclic Compounds (2002)

Article

Investigation of the Reaction of N-Acetylindoxyl with Substituted Anilines. Synthesis of Derivatives of Indolo[3,2-b]quinolines

1-Acetyl-2,3-dihydrospiro[indolo-3,2'-(1',2',3',4'-tetrahydroquinazolin-4'-one) was obtained from the reaction with anthranilamide, and 3-(2'-acetylaminophenyl)quinoxalin-2-one from the reaction with o-phenylened...

N. Z. Tugusheva, S. Yu. Ryabova, N. P. Solov'eva… in Chemistry of Heterocyclic Compounds (2001)

Article

One-pot synthesis of N-(3-coumarinoyl-)-N′-(salicylidene)hydrazines from 3-ethoxycarbonyl-(acyl)coumarins

M. P. Nemeryuk, V. D. Dimitrova, A. L. Sedov… in Chemistry of Heterocyclic Compounds (2000)

Article

Synthesis and investigation of the chemical and physicochemical properties of 6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2,3-dihydro-2-indolinones

Acylation of 1-ethyl-3-(N,N-dimethyl)aminomethylene-1,2-dihydro-2-indolinone by succinic anhydride in the presence of aluminum chloride has been studied. PMR spectroscopy shows that this acylation leads to for...

T. V. Golovko, N. P. Solov'eva, O. S. Anisimova… in Chemistry of Heterocyclic Compounds (1999)

Article

The original domestic drug oxolin: Refined structure of the drug and summarized experience of oxolin ointment use in medicine

R. G. Glushkov, T. A. Gus'kova, I. S. Nikolaeva… in Pharmaceutical Chemistry Journal (1999)