5 Result(s)
within
O. I. Volokh
Life Sciences
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Article
Cryo-EM Structure of Bovine Chaperonin TRiC/CCT in Open Conformation
In this work, conditions were selected for obtaining a sample of eukaryotic chaperonin TRiC suitable for studying by cryo-electron microscopy. Using the method of differential scanning (time-resolved) fluorime...
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Article
Investigation of the Effect of a Single-Stranded Break on the Mechanical Parameters of DNA by Molecular Dynamics Method
Early detection and repair of damaged DNA is important for cell functioning and survival. The recently proposed mechanism of intranucleosomal loop formation suggests the relaxation of DNA supercoiling accumula...
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Article
Purification and concentration of RNA polymerase on Ni-lipid monolayers
Knowledge of the chromatin transcription intermediate structures can shed light on the functioning of RNA polymerase in the cell, which is important both for basic science and for the development of therapeuti...
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Article
Structural studies of chromatin remodeling factors
Changes of chromatin structure require participation of chromatin remodeling factors (CRFs), which are ATP-dependent multisubunit complexes that change the structure of the nucleosome without covalently modify...
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Article
Study of RNA polymerase transcription through nucleosome using the cryo-electron microscopy approach
A promising and reliable method for the analysis of macromolecule structures is capturing images using cryo-electron transmission microscopy and consequently performing three-dimensional reconstructions. In th...
