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  1. No Access

    Article

    Cryo-EM Structure of Bovine Chaperonin TRiC/CCT in Open Conformation

    In this work, conditions were selected for obtaining a sample of eukaryotic chaperonin TRiC suitable for studying by cryo-electron microscopy. Using the method of differential scanning (time-resolved) fluorime...

    T. B. Stanishneva-Konovalova, E. B. Pichkur… in Moscow University Biological Sciences Bull… (2023)

  2. No Access

    Article

    Investigation of the Effect of a Single-Stranded Break on the Mechanical Parameters of DNA by Molecular Dynamics Method

    Early detection and repair of damaged DNA is important for cell functioning and survival. The recently proposed mechanism of intranucleosomal loop formation suggests the relaxation of DNA supercoiling accumula...

    O. I. Volokh, G. A. Armeev, E. S. Trifonova… in Moscow University Biological Sciences Bull… (2020)

  3. No Access

    Article

    Purification and concentration of RNA polymerase on Ni-lipid monolayers

    Knowledge of the chromatin transcription intermediate structures can shed light on the functioning of RNA polymerase in the cell, which is important both for basic science and for the development of therapeuti...

    M. G. Karlova, O. I. Volokh, O. V. Chertkov… in Russian Journal of Bioorganic Chemistry (2017)

  4. No Access

    Article

    Structural studies of chromatin remodeling factors

    Changes of chromatin structure require participation of chromatin remodeling factors (CRFs), which are ATP-dependent multisubunit complexes that change the structure of the nucleosome without covalently modify...

    O. I. Volokh, N. I. Derkacheva, V. M. Studitsky, O. S. Sokolova in Molecular Biology (2016)

  5. No Access

    Article

    Study of RNA polymerase transcription through nucleosome using the cryo-electron microscopy approach

    A promising and reliable method for the analysis of macromolecule structures is capturing images using cryo-electron transmission microscopy and consequently performing three-dimensional reconstructions. In th...

    O. I. Volokh, F. K. Hsieh, M. G. Karlova… in Moscow University Biological Sciences Bull… (2016)

  6. No Access

    Article

    Assessment of the DNA-binding properties of actinomycin and its derivatives by molecular dynamics simulation

    A molecular dynamics simulation was used to assess the effect on the elasticity of a DNA fragment and the efficiency of DNA binding for actinomycins (antibiotics that are used in chemotherapy for certain oncol...

    O. I. Volokh, M. E. Bozdaganyan, K. V. Shaitan in Biophysics (2015)

  7. No Access

    Article

    The molecular dynamics of N- and C-terminal interactions during autoinhibition and activation of formin mDial

    Steered molecular dynamics (SMD) was used to identify the interacting amino-acid residues on the surfaces of formin mDia1 domains for DID–DAD interactions, which is responsible for formin autoinhibition, and D...

    I. A. Orshanskiy, A. V. Popinako, A. D. Koromyslova, O. I. Volokh… in Biophysics (2015)