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Article
Open AccessThree transmission events of Vibrio cholerae O1 into Lusaka, Zambia
Cholera has been present and recurring in Zambia since 1977. However, there is a paucity of data on genetic relatedness and diversity of the Vibrio cholerae isolates responsible for these outbreaks. Understanding...
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Article
Open AccessA framework for assessing 16S rRNA marker-gene survey data analysis methods using mixtures.
There are a variety of bioinformatic pipelines and downstream analysis methods for analyzing 16S rRNA marker-gene surveys. However, appropriate assessment datasets and metrics are needed as there is limited gu...
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Article
Open AccessGenetic relatedness of Vibrio cholerae isolates within and between households during outbreaks in Dhaka, Bangladesh
Household contacts of cholera patients have a 100 times higher risk of develo** a cholera infection than the general population. To compare the genetic relatedness of clinical and water source Vibrio cholerae i...
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Article
Open AccessIndividual-specific changes in the human gut microbiota after challenge with enterotoxigenic Escherichia coli and subsequent ciprofloxacin treatment
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in inhabitants from low-income countries and in visitors to these countries. The impact of the human intestinal microbiota on the initiation an...
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Article
Open AccessPrevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia
Infectious diarrhea leads to significant mortality in children, with 40 % of these deaths occurring in Africa. Classic human astroviruses are a well-established etiology of diarrhea. In recent years, seven nov...
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Article
Open AccessDiarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition
Diarrheal diseases continue to contribute significantly to morbidity and mortality in infants and young children in develo** countries. There is an urgent need to better understand the contributions of novel...
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Chapter
Circulation and Transmission of Clones of Vibrio cholerae During Cholera Outbreaks
Cholera is still a major public health problem. The underlying bacterial pathogen Vibrio cholerae (V. cholerae) is evolving and some of its mutations have set the stage for outbreaks. After V. cholerae acquired t...
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Article
Differential abundance analysis for microbial marker-gene surveys
The metagenomeSeq tool robustly detects the differential abundance of microbes in marker-based microbial surveys by tackling the problems of data sparsity and undersampling common to these data sets.
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Article
Niche Partition of Bacteriovorax Operational Taxonomic Units Along Salinity and Temporal Gradients in the Chesapeake Bay Reveals Distinct Estuarine Strains
The predatory Bacteriovorax are Gram-negative bacteria ubiquitous in saltwater systems that prey upon other Gram-negative bacteria in a similar manner to the related genus Bdellovibrio. Among the phylogenetically...
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Article
Open AccessPolymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study
In a recent meta-analysis migraine was associated with a two-fold increase in stroke risk. While the mechanism driving this association is unknown, one intriguing hypothesis is that migraineurs are genetically...
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Article
Open AccessComparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence
Vibrio parahaemolyticus is a common cause of foodborne disease. Beginning in 1996, a more virulent strain having serotype O3:K6 caused major outbreaks in India and other parts of the world, resulting in the emerg...
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Article
Open AccessMolecular analysis of the emergence of pandemic Vibrio parahaemolyticus
Vibrio parahaemolyticus is abundant in the aquatic environment particularly in warmer waters and is the leading cause of seafood borne gastroenteritis worldwide. Prior to 1995, numerous V. parahaemolyticus serogr...
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Article
Open AccessLack of association between COMT gene and deficit/nondeficit schizophrenia
The dopamine dysregulation hypothesis of schizophrenia posits that positive, negative and cognitive symptoms correlate with cortical/subcortical imbalances in dopaminergic transmission. A functional polymorphi...
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Article
Open AccessA high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa
Malaria vaccine efficacy may be compromised if the frequency of non-target alleles increases following vaccination with a genetically polymorphic target. Methods are needed to monitor genetic diversity in poly...
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Article
Open AccessCLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity
Cystic fibrosis (CF) lung disease manifest by impaired chloride secretion leads to eventual respiratory failure. Candidate genes that may modify CF lung disease severity include alternative chloride channels. ...
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Article
Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12
The purpose of this study was to assess 65 pedigrees ascertained through a Bipolar I (BPI) proband for evidence of linkage, using nonparametric methods in a genome-wide scan and for possible parent of origin e...
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Chapter and Conference Paper
Mouse Models and Genetic Modifiers in X-Linked Adrenoleukodystrophy
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder that affects 1 in 35000 males and is marked by neurodegeneration, adrenal insufficiency and infertility. All characteristics are not always prese...
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Article
Characterization of Microbial Communities from Coastal Waters using Microarrays
Molecular methods, including DNA probes, were used to identify and enumerate pathogenic Vibrio species in the Chesapeake Bay; our data indicated that Vibrio vulnificus exhibits seasonal fluctuations in number. Ou...
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Chapter
Characterization of Microbial Communities from Coastal Waters Using Microarrays
Molecular methods, including DNA probes, were used to identify and enumerate pathogenic Vibrio species in the Chesapeake Bay; our data indicated that Vibrio vulnificus exhibits seasonal fluctuations in number. Ou...
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Article
Linkage of prostate cancer susceptibility loci to chromosome 1
Three prostate cancer susceptibility genes have been reported to be linked to different regions on chromosome 1: HPC1 at 1q24–25, PCAP at 1q42–43, and CAPB at 1p36. Replication studies analyzing each of these...
