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Article
Open AccessA Phase I-II multicenter trial with Avelumab plus autologous dendritic cell vaccine in pre-treated mismatch repair-proficient (MSS) metastatic colorectal cancer patients; GEMCAD 1602 study
Immune check-point blockade (ICB) has shown clinical benefit in mismatch repair-deficient/microsatellite instability high metastatic colorectal cancer (mCRC) but not in mismatch repair-proficient/microsatellit...
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Article
Open AccessEcological successions throughout the desiccation of Tirez lagoon (Spain) as an astrobiological time-analog for wet-to-dry transitions on Mars
Tirez was a small and seasonal endorheic athalassohaline lagoon that was located in central Spain. In recent years, the lagoon has totally dried out, offering for the first time the opportunity to analyze its ...
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Article
On the elemental composition of the Mediterranean euhalophyte Salicornia patula Duval-Jouve (Chenopodiaceae) from saline habitats in Spain (Huelva, Toledo and Zamora)
A complete survey is presented on the inorganic composition of the euhalophyte annual succulent species Salicornia patula (Chenopodiaceae), including materials from the Iberian Peninsula, littoral-coastal Tinto R...
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Article
Prevalence of levator ani avulsion in a multicenter study (PAMELA study)
The objective is to determine the prevalence of levator ani muscle (LAM) avulsion using four-dimensional ultrasound in primiparous women after vaginal delivery and according to delivery mode.
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Article
Open AccessAuthor Correction: Ultra-small microorganisms in the polyextreme conditions of the Dallol volcano, Northern Afar, Ethiopia
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Symbiotic human–robot collaborative approach for increased productivity and enhanced safety in the aerospace manufacturing industry
Robots are perfect substitutes for skilled workforce on some repeatable, general, and strategically important tasks, but this substitution is not always feasible. Despite the evolution of robotics, some indust...
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Article
Open AccessThe specific seroreactivity to ∆Np73 isoforms shows higher diagnostic ability in colorectal cancer patients than the canonical p73 protein
The p53-family is tightly regulated at transcriptional level. Due to alternative splicing, up to 40 different theoretical proteoforms have been described for p73 and at least 20 and 10 for p53 and p63, respect...
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Article
Open AccessUltra-small microorganisms in the polyextreme conditions of the Dallol volcano, Northern Afar, Ethiopia
The Dallol geothermal area in the northern part of the Danakil Depression (up to 124–155 meter below sea level) is deemed one of the most extreme environments on Earth. The area is notable for being part of th...
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Article
Numerical Modeling of the Impact of a Pumped-Storage Hydroelectric Power Plant on the Reservoirs’ Thermal Stratification Structure: a Case Study in NW Spain
Pumped-storage hydroelectric power plants are generally perceived as an environmentally respectful technology. Nevertheless, the pum** of water from a lower reservoir to an upper impoundment, and the return ...
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Article
Open AccessMicrobial mediated formation of Fe-carbonate minerals under extreme acidic conditions
Discovery of Fe-carbonate precipitation in Rio Tinto, a shallow river with very acidic waters, situated in Huelva, South-western Spain, adds a new dimension to our understanding of carbonate formation. Sedimen...
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Article
Localization of Nickel in Tissues of Streptanthus polygaloides Gray (Cruciferae) and Endemic Nickel Hyperaccumulators from California
The genus Streptanthus Nutt. is one of the most important indicators of ultramafic floras in western North America. This genus contains taxa that are endemic or tolerant of ultramafic soils. Streptanthus polygalo...
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Article
Open AccessMicrobial community composition of Tirez lagoon (Spain), a highly sulfated athalassohaline environment
The aim was to study the seasonal microbial diversity variations of an athalassohaline environment with a high concentration of sulfates in Tirez lagoon (La Mancha, Spain). Despite the interest in these types ...
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Article
An Improved Semiquantitative Method for Elemental Analysis of Plants Using Inductive Coupled Plasma Mass Spectrometry
A semiquantitative ICP-MS method suitable for evaluating metal content in plants exposed to high metal concentrations is described. The methodology which has been tested using different plant reference materia...
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Article
Metal Accumulation Screening of the Río Tinto Flora (Huelva, Spain)
Río Tinto (Huelva, Spain) is located in one of the most important mining regions in the world. Its soils are characterized by their extreme acidity and elevated concentrations of heavy metals. Due to these cha...
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Article
Spanish radiobiological pattern of care in lung cancer: a GOECP/SEOR study
A survey regarding radiobiological questions in the treatment of lung cancer (LC) was done to study the clinical aspects of radiotherapy in Spain, in order to standardise treatment decisions.
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Article
Lung Cancer OncoGuia
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Chapter
Subsurface Geomicrobiology of the Iberian Pyritic Belt
Terrestrial subsurface geomicrobiology is a matter of growing interest. On a fundamental level, it seeks to determine whether life can be sustained in the absence of radiation, whereas it also aims to develop ...
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Article
Posttraumatic giant renal pseudoaneurysm
Renal artery pseudoaneurysms secondary to blunt abdominal trauma are uncommon. We report a giant renal pseudoaneurysm, diagnosed by computerized tomography 5 months after a blunt trauma, which was confirmed by...
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Article
Nickel localization in tissues of different hyperaccumulator species of Euphorbiaceae from ultramafic areas of Cuba
Pantropical species of the genera Phyllanthus and Euphorbia and the Cuban endemic genus Leucocroton from the Euphorbiaceae family, were selected for nickel localization microanalysis. Scanning Electron Microscopy...
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Chapter and Conference Paper
Communication and Control for Reanimating Paralyzed Limbs via a Network of Wireless Micro-Implants
Functional reanimation of a paralyzed limb requires stimulation and sensing in multiple sites distributed throughout the limb. This paper describes a communication and control system for BION2™, a biomimetic s...
