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Article
Open AccessSLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex
SLITRK1 is an obsessive-compulsive disorder spectrum-disorders-associated gene that encodes a neuronal transmembrane protein. Here we show that SLITRK1 suppresses noradrenergic projections in the neonatal prefron...
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Chapter and Conference Paper
Abnormal Local Translation in Dendrites Impairs Cognitive Functions in Neuropsychiatric Disorders
Neurodegenerative disorders such as Huntington’ disease and frontotemporal lobar degeneration (FTLD) are often caused by aggregation of causative proteins and co-morbid with mental disorders of unknown origin....
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Article
Open AccessHippocampal function is not required for the precision of remote place memory
During permanent memory formation, recall of acquired place memories initially depends on the hippocampus and eventually become hippocampus-independent with time. It has been suggested that the quality of orig...
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Article
Open AccessZic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients
ZIC2 is a causal gene for holoprosencephaly and encodes a zinc-finger-type transcriptional regulator. We characterized Zic2kd/+ mice with a moderate (40%) reduction in Zic2 expression. Zic2kd/+ mice showed increa...
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Article
Open AccessDecreased postnatal neurogenesis in the hippocampus combined with stress experience during adolescence is accompanied by an enhanced incidence of behavioral pathologies in adult mice
Adolescence is a vulnerable period in that stress experienced during this time can affect the incidence of psychiatric disorders later, during adulthood. Neurogenesis is known to be involved in the postnatal d...
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Chapter
Transcription regulation of a Kunitz chymotrypsin inhibitor gene which is expressed abundantly in seeds and tuberous roots of winged bean
A winged bean Kunitz-type chymotrypsin inhibitor (WCI) accumulates abundantly in develo** embryos and tuberous roots, and also in a small amount in stems. Promoter activity of the 1.0 kbp upstream region of ...
