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Open AccessCorrection: Genome-wide DNA methylation analysis revealed stable DNA methylation status during decidualization in human endometrial stromal cells
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Article
Open AccessDifferential gene expression in decidualized human endometrial stromal cells induced by different stimuli
Decidualization can be induced by culturing human endometrial stromal cells (ESCs) with several decidualization stimuli, such as cAMP, medroxyprogesterone acetate (MPA) or Estradiol (E2). However, it has been unc...
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Article
Open AccessDifferent DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations
Somatic mutations in Mediator complex subunit 12 (MED12m) have been reported as a biomarker of uterine fibroids (UFs). However, the role of MED12m is still unclear in the pathogenesis of UFs. Therefore, we inv...
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Article
Open AccessFABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes
Fatty acid binding protein 7 (FABP7) is an intracellular fatty acid chaperon that is highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported that FABP7 re...
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Article
Prevalence of right ventricular outflow tract abnormalities among recipients in twin–twin transfusion syndrome after fetoscopic laser surgery in 90 consecutive cases
Right ventricular outflow tract obstruction (RVOTO) is a severe complication in recipients in twin–twin transfusion syndrome (TTTS). This study investigated the prevalence of RVOTO in TTTS after laser surgery ...
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Open AccessThe clinical outcome of Dienogest treatment followed by in vitro fertilization and embryo transfer in infertile women with endometriosis
Endometriosis is considered to be the most intractable cause of female infertility. Administering any type of treatment for endometriosis before in vitro fertilization and embryo transfer (IVF-ET) is an import...
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Article
SATB2 and NGR1: potential upstream regulatory factors in uterine leiomyomas
We attempted to identify the genes involved in the pathogenesis of uterine leiomyomas, under a hypothesis that the aberrant expression of upstream regulatory genes caused by aberrant DNA methylation is involve...
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Article
Open AccessGenome-wide DNA methylation analysis revealed stable DNA methylation status during decidualization in human endometrial stromal cells
During decidualization in endometrial stromal cells (ESCs), expressions of a number of genes and epigenetic modifications of histones are altered. However, there is little information about whether DNA methyla...
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Article
Open AccessAberrant DNA methylation suppresses expression of estrogen receptor 1 (ESR1) in ovarian endometrioma
In ovarian endometriomas (OE), the expression statuses of various steroid hormone receptors are altered compared with their expression statuses in eutopic endometrium (EE). For example, in OE, the expressions ...
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Article
Open AccessC/EBPβ regulates Vegf gene expression in granulosa cells undergoing luteinization during ovulation in female rats
The ovulatory LH-surge increases Vegf gene expression in granulosa cells (GCs) undergoing luteinization during ovulation. To understand the factors involved in this increase, we examined the roles of two transcri...
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Open AccessIdentification of uterine leiomyoma-specific marker genes based on DNA methylation and their clinical application
Differential diagnosis of uterine leiomyomas and leiomyosarcomas is needed to determine whether the uterus can be retained. Therefore, biomarkers for uterine leiomyomas and reliable and objective diagnostic me...
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Article
Open AccessChanges in gene expression of histone modification enzymes in rat granulosa cells undergoing luteinization during ovulation
The ovulatory LH surge rapidly alters the expression of steroidogenesis-related genes such as steroidogenic acute regulatory protein (StAR) in granulosa cells (GCs) undergoing luteinization. We recently reported ...
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Article
Open AccessHistone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis
Human histone H3.5 is a non-allelic H3 variant evolutionally derived from H3.3. The H3.5 mRNA is highly expressed in human testis. However, the function of H3.5 has remained poorly understood.
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Decidualization and Epigenetic Regulation
Decidualization is a process of differentiation of the endometrial stromal cells (ESC) accompanied by dramatic changes of cell functions and is necessary for embryo implantation and pregnancy establishment. A ...
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Article
Open AccessRetinoic acid has the potential to suppress endometriosis development
Despite endometriosis is common estrogen dependent disease afflicting women in reproductive age, the pathogenesis has not been fully elucidated. Retinoic acid has various functions in cells as biologic modulat...
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Article
Open AccessA pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis
Additional treatment with a gonadotropin-releasing hormone (GnRH) agonist (GnRHa) before IVF-ET (ultralong GnRHa therapy) has been reported to improve the outcome of IVF-ET in endometriosis patients. However, ...
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Open AccessLocally existing endothelial cells and pericytes in ovarian stroma, but not bone marrow-derived vascular progenitor cells, play a central role in neovascularization during follicular development in mice
Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascul...
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Open AccessA pilot study to prevent a thin endometrium in patients undergoing clomiphene citrate treatment
Clomiphene citrate (CC) is most commonly used as a first-line treatment of infertility. However, a disturbance of endometrial growth by the adverse effects of the CC has been recognized. Since a thin endometri...
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Article
Open AccessThe role of melatonin as an antioxidant in the follicle
Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night by pineal gland, and it regulates a variety of important central and peripheral actions related to circadian rhythms and repr...
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Article
Open AccessLuteal blood flow in patients undergoing GnRH agonist long protocol
Blood flow in the corpus luteum (CL) is closely related to luteal function. It is unclear how luteal blood flow is regulated. Standardized ovarian-stimulation protocol with a gonadotropin-releasing hormone ago...
