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  1. Article

    Open Access

    Development and preliminary validation of a prediction formula of sodium and sodium-to-potassium ratio based on multiple regression using 24-h urines

    Accurate measurement of sodium intake in the diet is challenging, and epidemiological studies can be hampered by the attenuation of associations due to measurement error in sodium intake. A prediction formula ...

    Marina Yamagishi, Ribeka Takachi, Junko Ishihara, Sachiko Maruya in Scientific Reports (2024)

  2. Article

    Open Access

    Fine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

    Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...

    Zhishan Chen, **ngyi Guo, Ran Tao, Jeroen R. Huyghe, Philip J. Law in Nature Communications (2024)

  3. Article

    Open Access

    Long-term use of anti-cholesterol drugs and cancer risks in a Japanese population

    Several studies have investigated the association between the use of anti-cholesterol drugs and cancer risks, of which results have been inconsistent. This study included 67,768 participants from the Japan Pub...

    Yuki Okita, Tomotaka Sobue, Ling Zha, Tetsuhisa Kitamura in Scientific Reports (2024)

  4. Article

    Open Access

    Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

    Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European a...

    Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C. Sakoda in Nature Communications (2023)

  5. Article

    Open Access

    Associations between fatty acid intake and diabetic retinopathy in a Japanese population

    Residents of Chikusei City, aged 40–74 years, underwent systemic and ophthalmological screening, and participants with diabetes were included in this analysis. Dietary intake was assessed using a food frequenc...

    Mariko Sasaki, Kenya Yuki, Akiko Hanyuda, Kazumasa Yamagishi in Scientific Reports (2023)

  6. Article

    Open Access

    Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

    Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...

    Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo in Nature Communications (2023)

  7. Article

    Open Access

    Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation

    Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-...

    Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N. Koyanagi in Scientific Reports (2023)

  8. Article

    Open Access

    Author Correction: Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies

    Yoko Yamagiwa, Keitaro Tanaka, Keitaro Matsuo, Keiko Wada in Scientific Reports (2023)

  9. Article

    Open Access

    Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies

    In Japan, hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and hepatitis C virus infection is a major cause of HCC. We conducted a systematic review and meta-analysis of published studies ...

    Yoko Yamagiwa, Keitaro Tanaka, Keitaro Matsuo, Keiko Wada in Scientific Reports (2023)

  10. Article

    Open Access

    Prevalence of family history of cancer in the NC-CCAPH consortium of Japan

    The objective of this study was to identify the prevalence of family history of cancer using cohorts participating in the Japanese National Center Cohort Collaborative for Advancing Population Health (NC-CCAPH...

    Sarah Krull Abe, Hikaru Ihira, Tetsuji Minami, Takuya Imatoh in Scientific Reports (2023)

  11. Article

    Open Access

    Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach

    The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduc...

    Ryoko Katagiri, Atsushi Goto, Shiori Nakano, Masahiro Nakatochi in Scientific Reports (2023)

  12. Article

    Open Access

    Prospective study of dietary changes in cancer survivors for five years including pre- and post- diagnosis compared with those in cancer-free participants

    The number of long-term survivors after a cancer diagnosis is increasing. Few investigations have compared survivors’ diets to their original pre-diagnosis dietary pattern or with the patterns of cancer-free c...

    Yuri Ishii, Ribeka Takachi, Junko Ishihara, Taiki Yamaji in Scientific Reports (2023)

  13. Article

    Open Access

    Green tea and coffee consumption and risk of kidney cancer in Japanese adults

    The study aimed to evaluate the association between green tea and coffee consumption and the risk of kidney cancer using data from a large prospective cohort study in Japan (the Japan Public Health Center-base...

    Yichi Chen, Sarah K. Abe, Manami Inoue, Taiki Yamaji, Motoki Iwasaki in Scientific Reports (2022)

  14. Article

    Open Access

    Relationship between blood pressure and intraocular pressure in the JPHC-NEXT eye study

    Although a positive link between hypertension and intraocular pressure (IOP) has been suggested, the individual effects of systolic and diastolic blood pressure (SBP and DBP, respectively) on IOP remain unclea...

    Tomoyo Yasukawa, Akiko Hanyuda, Kazumasa Yamagishi, Kenya Yuki in Scientific Reports (2022)

  15. Article

    Open Access

    Association between irregular daily routine and risk of incident stroke and coronary heart disease in a large Japanese population

    Circadian misalignments have been linked to adverse cardiometabolic outcomes. However, the association between irregular daily routine and the risk of cardiovascular disease (CVD) remains unknown. We examined ...

    Takahiro Yoshizaki, Junko Ishihara, Ayaka Kotemori, Yoshihiro Kokubo in Scientific Reports (2022)

  16. Article

    Open Access

    Sugary drink consumption and risk of kidney and bladder cancer in Japanese adults

    Globally, sugary drinks are widely consumed, however, few epidemiologic studies have investigated the association between sugary drink consumption and risk of kidney and bladder cancer. We examined the associa...

    Chi Yan Leung, Sarah Krull Abe, Norie Sawada, Junko Ishihara in Scientific Reports (2021)

  17. Article

    Open Access

    Reliability of self-reported questionnaire for epidemiological investigation of Helicobacter pylori eradication in a population-based cohort study

    General population-based cohort studies provide solid evidence on mass Helicobacter pylori (HP) eradication effects. Self-reported questionnaires are occasionally used in such studies to ascertain the HP eradicat...

    Yu Sasaki, Yasuhiko Abe, Masakuni Shoji, Naoko Mizumoto in Scientific Reports (2021)

  18. Article

    Open Access

    Serum anti-AP3D1 antibodies are risk factors for acute ischemic stroke related with atherosclerosis

    Atherosclerosis has been considered as the main cause of morbidity, mortality, and disability worldwide. The first screening for antigen markers was conducted using the serological identification of antigens b...

    Shu-Yang Li, Yoichi Yoshida, Eiichi Kobayashi, Masaaki Kubota in Scientific Reports (2021)

  19. Article

    Open Access

    Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study

    This population-based cross-sectional study was performed to determine the mean corneal endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX), and their associations with myopia...

    Naohiko Aketa, Miki Uchino, Motoko Kawashima, Yuichi Uchino in Scientific Reports (2021)

  20. Article

    Open Access

    Risk of stroke in cancer survivors using a propensity score-matched cohort analysis

    Little is known about the risk of cerebrovascular disease in cancer survivors. We aimed to assess the association between incident cancer and the subsequent risk of stroke using a large-scale, population-based...

    Eiko Saito, Manami Inoue, Norie Sawada, Yoshihiro Kokubo in Scientific Reports (2021)

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