5 Result(s)
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Article
Open AccessHACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells
HACE1, an E3 ubiquitin-protein ligase, is frequently inactivated and has been evidenced as a putative tumor suppressor in different types of cancer. However, its role in glioma remains elusive. Here, we observ...
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Open AccessSynergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAFV600E-driven human cancers
The activating TERT promoter mutations and BRAFV600E mutation are well-established oncogenic alterations in human cancers. Coexistence of BRAFV600E and TERT promoter mutations is frequently found in multiple canc...
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Open AccessCYP2S1 is a synthetic lethal target in BRAFV600E-driven thyroid cancers
BRAFV600E is the most common genetic alteration and has become a major therapeutic target in thyroid cancers; however, intrinsic feedback mechanism limited clinical use of BRAFV600E specific inhibitors. Synthetic...
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Article
Open AccessInjectable hydrogels for cartilage and bone tissue engineering
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potenti...
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Open AccessRecent advances in nano scaffolds for bone repair
Biomedical applications of nanomaterials are exponentially increasing every year due to analogy to various cell receptors, ligands, structural proteins, and genetic materials (that is, DNA). In bone tissue, na...
