12 Result(s)
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Open AccessCytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers
The aim of this study was to investigate the expression of the nuclear receptor PPARγ, together with that of the cyclooxygenases Cox-1 and Cox-2, in breast cancer (BC) tissues and to correlate the data with se...
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Open AccessEP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer
In various cancers, overexpression of cyclooxygenase (COX)-2 and elevated prostaglandin (PG) E2 synthesis have been associated with tumor development and progression. The potential of COX-2 inhibitors in cance...
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Open AccessTesting chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids
Targeted anti-HER2 therapy has greatly improved the prognosis for many breast cancer patients. However, treatment for HER2 negative disease is currently still selected from a multitude of untargeted chemothera...
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LIFESTYLE und erblicher Brustkrebs
Nicht für alle Trägerinnen einer Mutation in den Genen BRCA1 und BRCA2 liegt das lebenslange Erkrankungsrisiko für Brust- oder Eierstockkrebs gleich hoch. Bislang werden jedoch bei der Indikationsstellung zur Tei...
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Open AccessProspective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy – the SpheroNEO study
Aim of this prospective study was to predict response to neoadjuvant therapy in breast cancer patients using an in vitro breast cancer spheroid model.
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Article
Effect of optical clearing agents on optical coherence tomography images of cervical epithelium
Optical coherence tomography (OCT) can be used as an adjunct to colposcopy in order to detect precancerous and cancerous cervical lesions. Optical clearing agents (OCAs) temporarily reduce the optical scatteri...
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Effect of acetic acid on optical coherence tomography (OCT) images of cervical epithelium
Optical coherence tomography (OCT) can be used as an adjunct to colposcopy in the identification of precancerous and cancerous cervical lesions. The purpose of this study was to investigate the effect of aceti...
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Open AccessImmunosuppressive Glycodelin A is an independent marker for poor prognosis in endometrial cancer
Knowledge on immunosuppressive factors in the pathogenesis of endometrial cancer is scarce. The aim of this study was to assess Glycodelin (Gd) and its immunosuppressive isoform Glycodelin A (GdA) in endometri...
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Open AccessMulticentric and multifocal versusunifocal breast cancer: differences in the expression of E-cadherin suggest differences in tumor biology
The aim of this study was to evaluate the expression of the cell adhesion-related glycoproteins MUC-1, β-catenin and E-cadherin in multicentric/multifocal breast cancer in comparison to unifocal disease in ord...
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Open AccessSteroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival
There is partially conflicting evidence on the influence of the steroid hormones estrogen (E) and progesterone (P) on the development of ovarian cancer (OC). The aim of this study was to assess the expression ...
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Article
Open AccessHuman chorionic gonadotropin and its relation to grade, stage and patient survival in ovarian cancer
An influence of gonadotropins (hCG) on the development of ovarian cancer has been discussed. Therefore, we quantified serum hCG levels in patients with benign and malignant ovarian tumors and the hCG expressio...
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Open AccessNuclear receptor coregulator SNP discovery and impact on breast cancer risk
Coregulator proteins are "master regulators", directing transcriptional and posttranscriptional regulation of many target genes, and are critical in many normal physiological processes, but also in hormone dri...
