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  1. No Access

    Article

    Oxidants, oxidative stress and the biology of ageing

    Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence ...

    Toren Finkel, Nikki J. Holbrook in Nature (2000)

  2. No Access

    Article

    Activation of the cholesterol pathway and Ras maturation in response to stress

    All cells depend on sterols and isoprenoids derived from mevalonate (MVA) for growth, differentiation, and maintenance of homeostatic functions. In plants, environmental insults like heat and sunlight trigger ...

    Sonsoles Shack, Myriam Gorospe, Timothy W Fawcett, W Robert Hudgins… in Oncogene (1999)

  3. No Access

    Article

    The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract

    Both DR4 and DR5 have recently been identified as membrane death receptors that are activated by their ligand TRAIL to engage the intracellular apoptotic machinery. TRID (also named as TRAIL-R3) is an antagoni...

    M Saeed Sheikh, Ying Huang, Ester A Fernandez-Salas, Wafik S El-Deiry… in Oncogene (1999)

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    Article

    Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells

    The mechanism of Taxol-induced apoptosis was investigated in MCF-7 human breast carcinoma cells. Taxol-induced apoptosis was associated with phosphorylation of both c-Raf-1 and Bcl-2 and activation of ERK and ...

    Ying Huang, M Saeed Sheikh, Albert J Fornace Jr, Nikki J Holbrook in Oncogene (1999)

  5. No Access

    Chapter

    Posttranslational Mechanisms Leading to Mammalian Gene Activation in Response to Genotoxic Stress

    Exposure of cells to treatments or agents that damage DNA evokes changes in gene expression. These effects were first documented in bacteria, but similar responses occur in unicellular (see Chapters 7 and 18 in v...

    Yusen Liu, Myriam Gorospe, Nikki J. Holbrook, Carl W. Anderson in DNA Damage and Repair (1998)

  6. No Access

    Article

    p27Kip1 overexpression causes apoptotic death of mammalian cells

    p27Kip1, a member of the Cip/Kip family of cyclin-dependent kinase (cdk) inhibitors, has been implicated in mediating G1 arrest in response to a variety of growth inhibitory signals. Its importance in regulating ...

    **antao Wang, Myriam Gorospe, Ying Huang, Nikki J Holbrook in Oncogene (1997)

  7. No Access

    Article

    p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

    The tumor suppressive effect of p53 is believed to be rooted in its two primary functions: the implementation of cellular growth arrest and the execution of apoptotic cell death. While p53-regulated expression...

    Myriam Gorospe, Corrado Cirielli, **antao Wang, Prem Seth… in Oncogene (1997)

  8. No Access

    Chapter

    Heat Shock Protein Expression in the Aging Cardiovascular System

    Mammalian aging is accompanied by a progressive decline in most physiologic functions and in particular by a decreased ability to maintain homeostasis when faced with conditions of stress (Shock et al., 1984; ...

    Nikki J. Holbrook, Timothy W. Fawcett… in Heat Shock Proteins and the Cardiovascular… (1997)