-
Article
A biobank of small cell lung cancer CDX models elucidates inter- and intratumoral phenotypic heterogeneity
Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes were recently defined by neuroen...
-
Article
Easing anxiety in preparation for pediatric magnetic resonance imaging: a pilot study using animal-assisted therapy
Children undergoing magnetic resonance imaging (MRI) can experience negative emotions both before and during their scan, causing them to move and often necessitating the use of procedural sedation. Several str...
-
Article
Open AccessSignaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin
Precision medicine aims to tailor cancer therapies to target specific tumor-promoting aberrations. For tumors that lack actionable drivers, which occurs frequently in the clinic, extensive molecular characteri...
-
Article
Open AccessVasculogenic mimicry in small cell lung cancer
Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing v...
