-
Article
Open AccessTelNet - a database for human and yeast genes involved in telomere maintenance
The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract th...
-
Article
Investigation of the spatial structure and interactions of the genome at sub-kilobase-pair resolution using T2C
This protocol describes targeted chromatin capture (T2C), a high-resolution method to interrogate 3D chromatin organization and genomic interactions at sub-kilobase-pair resolution that requires minimal cell n...
-
Article
Open AccessThe detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes
The dynamic three-dimensional chromatin architecture of genomes and its co-evolutionary connection to its function—the storage, expression, and replication of genetic information—is still one of the central i...
-
Article
Open AccessTargeted Chromatin Capture (T2C): a novel high resolution high throughput method to detect genomic interactions and regulatory elements
Significant efforts have recently been put into the investigation of the spatial organization and the chromatin-interaction networks of genomes. Chromosome conformation capture (3C) technology and its derivati...
-
Chapter and Conference Paper
Visualization in Health Grid Environments: A Novel Service and Business Approach
Advanced visualization technologies are gaining major importance to allow presentation and manipulation of high dimensional data. Since new health technologies are constantly increasing in complexity, adequate...
