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Article
Open AccessStrategies to improve implementation of cascade testing in hereditary cancer syndromes: a systematic review
Hereditary cancer syndromes constitute approximately 10% of all cancers. Cascade testing involves testing of at-risk relatives to determine if they carry the familial pathogenic variant. Despite growing effort...
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Article
Open AccessProcess evaluation of a tailored nudge intervention to promote appropriate care and treatment of older patients at the end-of-life
Non-beneficial treatment affects a considerable proportion of older people in hospital, and some will choose to decline invasive treatments when they are approaching the end of their life. The Intervention for...
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Article
Open AccessFrom pilot to a multi-site trial: refining the Early Detection of Deterioration in Elderly Residents (EDDIE +) intervention
Early Detection of Deterioration in Elderly Residents (EDDIE +) is a multi-modal intervention focused on empowering nursing and personal care workers to identify and proactively manage deterioration of residen...
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Article
Economic Evaluations of Imaging Biomarker-Driven Companion Diagnostics for Cancer: A Systematic Review
There is a boom in imaging biomarker-driven companion and complementary diagnostics (CDx) for cancer, which brings opportunity for personalized medicine. Whether adoption of these technologies is likely to be ...
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Living Reference Work Entry In depth
A Systematic Review and Case Studies of Health and Social Services Provided for Community-Dwelling Older Adults
In Singapore, rapid population aging is generating increased research and policy attention toward promoting aging in place. Individuals who grow older in familiar communities are more likely to be socially eng...
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Article
Open AccessImpact of a prospective feedback loop on care review activities in older patients at the end of life. A stepped-wedge randomised trial
Hospitalisation rates for older people are increasing, with end-of-life care becoming a more medicalised experience. Innovative approaches are warranted to support early identification of the end-of-life phase...
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Article
Open AccessA systematic review defining non-beneficial and inappropriate end-of-life treatment in patients with non-cancer diagnoses: theoretical development for multi-stakeholder intervention design in acute care settings
Non-beneficial treatment is closely tied to inappropriate treatment at the end-of-life. Understanding the interplay between how and why these situations arise in acute care settings according to the various st...
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Article
Open AccessThe clinical value and cost-effectiveness of treatments for patients with coronary artery disease
The clinical value and cost-effectiveness of invasive treatments for patients with coronary artery disease is unclear. Invasive treatments such as coronary artery bypass grafting and percutaneous coronary inte...
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Article
Open AccessReducing waste in collection of quality-of-life data through better reporting: a case study
This study describes the reporting of the preference-based health-related quality-of-life (HRQOL) instrument, the EQ-5D, and proposes strategies to improve reporting and reduce research waste. The EQ-5D is a v...
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Article
Open AccessBuilding Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview
Review building of programs to eliminate Toxoplasma infections.
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Article
Open AccessProbabilistic microsimulation to examine the cost-effectiveness of hospital admission screening strategies for carbapenemase-producing enterobacteriaceae (CPE) in the United Kingdom
Antimicrobial resistance has been recognised as a global threat with carbapenemase- producing-Enterobacteriaceae (CPE) as a prime example. CPE has similarities to COVID-19 where asymptomatic patients may be co...
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Article
Open AccessBuilding Programs to Eradicate Toxoplasmosis Part II: Education
Review work to create and evaluate educational materials that could serve as a primary prevention strategy to help both providers and patients in Panama, Colombia, and the USA reduce disease burden of Toxoplasma ...
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Article
Open AccessBuilding Programs to Eradicate Toxoplasmosis Part III: Epidemiology and Risk Factors
Review comprehensive data on rates of toxoplasmosis in Panama and Colombia.
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Article
Open AccessBuilding Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”
Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health.
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Article
Economic Evaluation of an Intervention Designed to Reduce Bullying in Australian Schools
There is a shortage of information on the costs and benefits of anti-bullying programs implemented in Australia. Information on the costs and benefits of anti-bullying programs is vital to assist policy making...
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Article
Open AccessDevelopment and validation of a risk index to predict kidney graft survival: the kidney transplant risk index
Kidney graft failure risk prediction models assist evidence-based medical decision-making in clinical practice. Our objective was to develop and validate statistical and machine learning predictive models to p...
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Article
Open AccessA stepped-wedge randomised controlled trial assessing the implementation, effectiveness and cost-consequences of the EDDIE+ hospital avoidance program in 12 residential aged care homes: study protocol
Older people living in residential aged care homes experience frequent emergency transfers to hospital. These events are associated with risks of hospital acquired complications and invasive treatments or inte...
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Article
Open AccessA cross sectional study of organizational factors and their impact on job satisfaction and emotional burnout in a group of Australian nurses: infection control practitioners
Infection control practitioners (ICPs) are a group of specialized nurses fundamental to effective healthcare infection prevention and control initiatives. Relative to other groups of nurses much less is known ...
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Article
Open AccessTime-to-event analysis in economic evaluations: a comparison of modelling methods to assess the cost-effectiveness of transplanting a marginal quality kidney
Economic-evaluations using decision analytic models such as Markov-models (MM), and discrete-event-simulations (DES) are high value adds in allocating resources. The choice of modelling method is critical beca...
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Article
Open AccessThe effectiveness and cost effectiveness of a hospital avoidance program in a residential aged care facility: a prospective cohort study and modelled decision analysis
Residential aged care facility residents experience high rates of hospital admissions which are stressful, costly and often preventable. The EDDIE program is a hospital avoidance initiative designed to enable ...
