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  1. No Access

    Protocol

    Exploring Enzyme Evolution from Changes in Sequence, Structure, and Function

    The goal of our research is to increase our understanding of how biology works at the molecular level, with a particular focus on how enzymes evolve their functions through adaptations to generate new specific...

    Jonathan D. Tyzack, Nicholas Furnham… in Computational Methods in Protein Evolution (2019)

  2. Protocol

    Complementary Sources of Protein Functional Information: The Far Side of GO

    The GO captures many aspects of functional annotations, but there are other alternative complementary sources of protein function information. For example, enzyme functional annotations are described in a rang...

    Nicholas Furnham in The Gene Ontology Handbook (2017)

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  3. No Access

    Article

    EC-BLAST: a tool to automatically search and compare enzyme reactions

    EC-BLAST is a Web-based tool allowing quantitative similarity searches between enzymes at the levels of bond-change, reaction-center or reaction-structure similarity. The tool may help improve the annotation o...

    Syed Asad Rahman, Sergio Martinez Cuesta, Nicholas Furnham… in Nature Methods (2014)

  4. Article

    Open Access

    Comparative modelling by restraint-based conformational sampling

    Although comparative modelling is routinely used to produce three-dimensional models of proteins, very few automated approaches are formulated in a way that allows inclusion of restraints derived from experime...

    Nicholas Furnham, Paul IW de Bakker, Swanand Gore, David F Burke… in BMC Structural Biology (2008)

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  5. No Access

    Article

    Is one solution good enough?

    Nicholas Furnham, Tom L Blundell, Mark A DePristo… in Nature Structural & Molecular Biology (2006)