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Chapter
The Discovery of the Biological Synthesis of Nitric Oxide
We have reviewed the experimental work reported through 1988 that provided the foundation for the new field of NO* biology. In addition, we have described experiments carried out between 1988 and 1990 that led di...
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Chapter
Interactions Between Cytokine Induced Nitric Oxide and Intracellular Iron
Cooperation between macrophages and T-lymphocytes is necessary for the development of cell-mediated immune (CMI) responses (Hibbs et al., 1990). It has long been understood that the CMI response is important i...
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Chapter
Identification of Nitric Oxide-Derived EPR Signals in Human Cancers
Progressively growing cancers in animals and humans often have significant infiltration by host macrophages (Svennevig et al., 1979;; Wood & Gillespie, 1975; Eccles & Alexander, 1974a). Conflicting data exist ...
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Chapter
Nitric Oxide Effects on Murine Cardiac Allografts
Biosynthesis of nitric oxide (NO) by mammalian cells has recently been demonstrated (Hibbs et al., 1987a; Iyengar et al., 1987; Hibbs et al., 1988; Marietta et al., 1988). NO synthesis is induced during a cell...
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Chapter
Induction of Iron-Nitric Oxide EPR Signals in Murine Cancers: Effects of Thiols and Cytokine-Induced Oxidant Stress
Murine lymphocytes incubated for three to four days with Interleukin-2 (IL-2) have enhanced tumoricidal activity and are called lymphocyte activated killer (LAK) cells (Lotze et al., 1981; Rosenstein & Rosenbe...
