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Article
Open AccessAssociations of Cannabis Use, High-Risk Alcohol Use, and Depressive Symptomology with Motivation and Attempts to Quit Cigarette Smoking Among Adults: Findings from the 2020 ITC Four Country Smoking and Va** Survey
This study assessed independent and interaction effects of the frequency of cannabis use, high-risk alcohol use, and depressive symptomology on motivation and attempts to quit cigarette smoking among adults wh...
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Article
Nicotine e-cigarettes as a tool for smoking cessation
There is abundant evidence that e-cigarettes can help some individuals to quit smoking, so they should be more widely recommended as smoking cessation aids.
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Article
Va** THC-O Acetate: Potential for Another EVALI Epidemic
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Article
Open AccessAnalyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans
Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3′hydroxycotinine. The Nicotine Metabolite Ratio (NMR; 3′hydroxycotinine/cotinine) is a heritable nicotine metabolism biomarker,...
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Article
Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers
It is unclear why Black smokers in the United States have elevated risk of some tobacco-related diseases compared to White smokers. One possible causal mechanism is differential intake of tobacco toxicants, bu...
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Article
Effect of e-cigarette flavors on nicotine delivery and puffing topography: results from a randomized clinical trial of daily smokers
There is limited understanding regarding how various e-cigarette flavorings may influence the behavior of non-regular e-cigarette users who are regular cigarette smokers.
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Article
Effect of γ-hydroxybutyrate (GHB) on driving as measured by a driving simulator
Gamma-hydroxybutyrate acid (GHB), a GABAB receptor agonist approved for treatment of narcolepsy, impairs driving ability, but little is known about doses and plasma concentrations associated with impairment and t...
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Article
Slower nicotine metabolism among postmenopausal Polish smokers
A non-invasive phenotypic indicator of the rate of nicotine metabolism is nicotine metabolite ratio (NMR) defined as a ratio of two major metabolites of nicotine — trans-3′-hydroxycotinine/cotinine. The rate of n...
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Article
Cardiovascular effects of electronic cigarettes
The population risk versus benefit for use of electronic cigarettes (ECs) is strongly influenced by the relative safety of ECs compared with conventional cigar...
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Article
Very Low Nicotine Content Cigarettes and Potential Consequences on Cardiovascular Disease
Cigarette smoking remains highly prevalent in the U.S. and contributes significantly to cardiovascular disease (CVD). Tobacco control policies, including product regulation, can reduce smoking-related harm. On...
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Article
Gene-Centric Analysis of Serum Cotinine Levels in African and European American Populations
To date, most genetic association studies of tobacco use have been conducted in European American subjects using the phenotype of smoking quantity (cigarettes per day). However, smoking quantity is a very impr...
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Article
Open AccessSmoking Cessation Pharmacogenetics: Analysis of Varenicline and Bupropion in Placebo-Controlled Clinical Trials
Despite effective therapies for smoking cessation, most smokers find quitting difficult and most successful quitters relapse. Considerable evidence supports a genetic risk for nicotine dependence; however, les...
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Article
Open AccessDesign, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data
African Americans experience significant tobacco-related health disparities despite the fact that over half of African American smokers are light smokers (use ≤10 cigarettes per day). African Americans have be...
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Article
Dopamine Genes and Nicotine Dependence in Treatment-Seeking and Community Smokers
We utilized a cohort of 828 treatment-seeking self-identified white cigarette smokers (50% female) to rank candidate gene single nucleotide polymorphisms (SNPs) associated with the Fagerström Test for Nicotine...
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Chapter
Nicotine Chemistry, Metabolism, Kinetics and Biomarkers
Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a pharmacological aid to smoking cessation. The absorption, distribution and disposition characteristics of nicotine from t...
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Article
Creating and evaluating genetic tests predictive of drug response
Recent advances in genomic knowledge and associated technologies should help accelerate the development of genetic tests that can predict drug response and toxicity; however several challenges remain. Here, We...
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Article
Dietary supplement adverse events: Report of a one-year poison center surveillance project
The safety and efficacy of dietary supplements is of growing concern to regulators, health-care providers and consumers. Few scientific data exist on clinical effects and potential toxicities of marketed produ...
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Article
Translational research in medication development for nicotine dependence
Nicotine dependence is a major public health problem. Food and Drug Administration (FDA)-approved medications include nicotine-replacement therapies, bupropion...
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Article
Population Pharmacokinetics of Nicotine and Its Metabolites I. Model Development
We present a mechanistic population model for the pharmacokinetics of nicotine (NIC), its primary (CYP2A6-generated) metabolite cotinine (COT), and COT’s primary (CYP2A6-generated) metabolite, trans-3′-hydroxy...
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Article
Prediction Methods for Nicotine Clearance Using Cotinine and 3-Hydroxy-Cotinine Spot Saliva Samples II. Model Application
To develop and compare methods that predict individual nicotine (NIC) clearance, which reflects CYP2A6 activity, using random saliva cotinine (COT) and trans 3′-hydroxycotinine (3HC) measurements. COT and 3HC ...
