4 Result(s)
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Article
Open AccessGenetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study
Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer’s disease (AD). We aimed to evaluate the potential causal role of TL in AD ...
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Article
Open AccessPerivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum
Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechan...
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Article
Open AccessCognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer’s continuum is crucial to develop therapeutic and preventive strategies. The o...
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Article
Open AccessStrategies to reduce sample sizes in Alzheimer’s disease primary and secondary prevention trials using longitudinal amyloid PET imaging
Detecting subtle-to-moderate biomarker changes such as those in amyloid PET imaging becomes increasingly relevant in the context of primary and secondary prevention of Alzheimer’s disease (AD). This work aimed...
