9 Result(s)

Article

APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals

To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants.

Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Raffaele Cacciaglia… in EJNMMI Research (2023)

Article

Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum

Glial activation is one of the earliest mechanisms to be altered in Alzheimer’s disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal f...

Gemma Salvadó, Marta Milà-Alomà… in European Journal of Nuclear Medicine and M… (2022)

Article

Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease

Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó… in Nature Medicine (2022)

Article

Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease

Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer’s disease are needed to facilitate the initial screening process of participants in disease-modifying trials. Previous bio...

Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó… in Nature Medicine (2022)

Article

Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts

Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer’s continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Y...

Raffaele Cacciaglia, Gemma Salvadó, José Luis Molinuevo… in Molecular Psychiatry (2022)

Article

Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum

Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechan...

Natalia Vilor-Tejedor, Iacopo Ciampa, Grégory Operto… in Alzheimer's Research & Therapy (2021)

Article

Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile

Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer’s continuum is crucial to develop therapeutic and preventive strategies. The o...

Marta Milà-Alomà, Mahnaz Shekari, Gemma Salvadó… in Alzheimer's Research & Therapy (2021)

Article

Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer’s disease

Recognizing clinical manifestations heralding the development of Alzheimer’s disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...

Oriol Grau-Rivera, Irene Navalpotro-Gomez… in Alzheimer's Research & Therapy (2021)

Article

Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study

Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association ...

Natalia Vilor-Tejedor, Grégory Operto, Tavia E. Evans… in Brain Structure and Function (2020)