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26 Result(s)
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Natàlia Garcia-Reyero
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Article
Open AccessSystematic assessment of long-read RNA-seq methods for transcript identification and quantification
The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. Using different protocols and sequencing platf...
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Article
Open AccessMale fathead minnow transcriptomes and associated chemical analytes in the Milwaukee estuary system
Contaminants of Emerging Concern (CECs) can be measured in waters across the United States, including the tributaries of the Great Lakes. The extent to which these contaminants affect gene expression in aquati...
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Chapter and Conference Paper
A Fuzzy Epigenetic Model for Representing Degradation in Engineered Systems
Degradation processes are implicated in a large number of system failures, and are thus crucial to understanding issues related to reliability and safety. Systems typically degrade in response to stressors, su...
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Article
Open AccessPublisher Correction: Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessTargeting redox metabolism: the perfect storm induced by acrylamide poisoning in the brain
Exposure to acrylamide may lead to different neurotoxic effects in humans and in experimental animals. To gain insights into this poorly understood type of neurotoxicological damage, we used a multi-omic appro...
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Article
Open AccessTherapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish
Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and the dep...
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Article
Open AccessKeanu: a novel visualization tool to explore biodiversity in metagenomes
One of the main challenges when analyzing complex metagenomics data is the fact that large amounts of information need to be presented in a comprehensive and easy-to-navigate way. In the process of analyzing F...
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Book
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Book
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Protocol
Overview of Gene Expression Analysis: Transcriptomics
Currently, the study of the transcriptome is widely used to interpret the functional elements of the genome and molecular constituents of cells and tissues in an effort to unravel biological pathways associate...
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Chapter
Use of Genetic Manipulation for Evaluating and Understanding Adverse Outcome Pathways
Innovations in biology have brought forth a new era of genetic manipulation ranging from the creation of molecular scissors for targeted single-nucleotide alterations, to a simultaneous inactivation of 62 gene...
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Chapter
Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A Conceptual Model
Ecological risk assessment quantifies the likelihood of undesirable impacts of stressors, primarily at high levels of biological organization. Data used to inform ecological risk assessments come primarily fro...
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Chapter
The Future of Adverse Outcome Pathways: Analyzing their Social Context
This chapter places the development of adverse outcome pathways (AOPs) in their social context. It begins by highlighting the intense social and political polarization that currently exists around environmenta...
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Chapter
Advancing Adverse Outcome Pathways for Risk Assessment
The Adverse Outcome Pathway (AOP) framework was first proposed by Ankley and colleagues back in 2010 (Ankley et al. Environ Toxicol Chem 29:730–741, 2010). AOPs organize information across biological levels of...
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Article
Open AccessModelling acrylamide acute neurotoxicity in zebrafish larvae
Acrylamide (ACR), a type-2 alkene, may lead to a synaptopathy characterized by ataxia, skeletal muscles weakness and numbness of the extremities in exposed human and laboratory animals. Currently, only the mil...
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Article
Advancing Ecotoxicology in the US Southern States
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Article
Open AccessTargeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes
Zebrafish models for mild, moderate, and severe acute organophosphorus poisoning were previously developed by exposing zebrafish larvae to chlopyrifos-oxon. The phenotype of these models was characterized at s...
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Article
Open AccessCorrection: Corrigendum: Zebrafish Models for Human Acute Organophosphorus Poisoning
Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, e...
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Article
Open AccessZebrafish Models for Human Acute Organophosphorus Poisoning
Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, e...
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Protocol
The Adverse Outcome Pathway: A Conceptual Framework to Support Toxicity Testing in the Twenty-First Century
The need to rapidly characterize the risk of large numbers of chemicals has moved the traditional toxicological paradigm from animal testing to a pathway-based approach using in vitro assay systems and modelin...
