19 Result(s)
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Nasreen Z. Ehtesham
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Article
Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females
The mechanisms contributing to recurrence of glioblastoma (GBM), an aggressive neuroepithelial brain tumor, remain unknown. We have recently shown that nuclear respiratory factor 1 (NRF1) is an oncogenic trans...
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Chapter
Global Biologic Characteristics of Variants of Concern and Variants of Interest of SARS-CoV-2
By mid-2020, during the spread of COVID-19 pandemic, selective sweep of D614G variant of SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus) was observed around the globe. The D614G variant, compared to...
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Article
SARS-CoV-2 variants of concern are emerging in India
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Chapter
Next Generation Sequencing: Opportunities and Challenges in Tuberculosis Research
Despite a reasonable reduction in tuberculosis incidence and mortality in the last few years, the disease remains to be the major global public health challenge. The advent and transmission of drug-resistant t...
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Chapter
Emerging Transcriptomic Approaches to Decipher Mycobacterial Complexities
The word “transcriptome” generally refers to overall RNA species transcribed from DNA (or RNA itself) or transcripts that are present in a cell. The transcriptome includes messenger RNA (mRNA), ribosomal RNA (...
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Chapter
Exploration of the Mycobacterial Proteome in the Pathogenesis of TB: A Perspective
Tuberculosis caused by Mycobacterium tuberculosis (M. tb) with a global burden of 10 million cases in 2019 causes morbidity and mortality if not treated. The constant rise in drug-resistant TB has further aggrava...
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Article
Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities
Nuclear respiratory factor 1 (NRF1) drives estrogen-dependent breast tumorigenesis. Herein we examined the impact of NRF1 activity on the aggressiveness and disparate molecular signature of breast cancer in Bl...
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Article
Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma
Despite tremendous progress in understanding the pathobiology of astrocytoma, major gaps remain in our knowledge of the molecular basis underlying the aggressiveness of high-grade astrocytoma (glioblastoma - G...
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Article
Open AccessPeptidyl-prolyl isomerase-B is involved in Mycobacterium tuberculosis biofilm formation and a generic target for drug repurposing-based intervention
Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (M.tb), takes one human life every 15 s globally. Disease relapse occurs due to incomplete clearance of the pathogen and reactivation of the antib...
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Chapter
Breaking the Transmission of TB: A Roadmap to Bridge the Gaps in Controlling TB in Endemic Settings
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains an enormous health burden with nearly 2 billion people worldwide being affected by it, though only 10% progress to active disease. Currently...
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Chapter
Mycobacterial Methyltransferases: Significance in Pathogenesis and Virulence
Mycobacterium tuberculosis (M.tb) is a pathogen of incredible international prominence owing to its persistence for long duration inside human host in both active and latent form, complex eradication methods and ...
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Chapter
Intrinsically Disordered Regions in PE/PPE Protein Family of Mycobacterium tuberculosis: Moonlighting Function
Mycobacterium tuberculosis, the causative agent of tuberculosis, has the distinction of harboring an unusual set of plentiful antigens that are highly homologous. The abundance of similar proteins like PE/PPE tha...
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Chapter
Endoplasmic Reticulum Stress: Importance in Pathogenesis of Mycobacterium tuberculosis
Mycobacterium tuberculosis (M.tb), the cause of deadly disease tuberculosis, is an opportunistic pathogen that primarily infects host alveolar macrophages. M.tb has developed several mechanisms to persist in infe...
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Chapter
Biofilms: A Phenotypic Mechanism of Bacteria Conferring Tolerance Against Stress and Antibiotics
Biofilm, as a heterogenous congregation of microbial cells enclosed within a pellicle, has largely gained attention due to their historical importance in environment as sludges, flocs, slimes, etc. Biofilms in...
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Article
Open AccessEmerging importance of holobionts in evolution and in probiotics
The existence of microbe free animals or plants in nature is virtually impossible as they and plants have a certain degree of symbiotic association with microbes. This symbiotic association leads to the format...
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Article
Expression, purification and ligand binding properties of the recombinant translation initiation factor (PeIF5B) from Pisum sativum
Gene encoding a novel translation initiation factor PeIF5B from Pisum sativum with sequence similarity to eIF5B from H. sapiens, D. melanogaster, S. cerevisiae as well as archaeal aIF5B from M. thermoautotrophicu...
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Article
Characterization of LEF4 ligand binding property and its role as part of baculoviral transcription machinery
Late expression factor 4 (LEF4) is one of the four identified subunits of Autographa californica nucleopolyhedrosis virus (AcNPV) encoded RNA polymerase that carries out transcription from viral late and very lat...
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Article
Single-nucleotide polymorphisms in peroxisome proliferator-activated receptor γ and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPARγ with diabetes and obesity have revealed extensive population-dependent variations. However, association of these polymorphisms with the...
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Chapter and Conference Paper
A Multi-locus Probe for Human DNA Fingerprinting Based on chi-like Sequences
DNA fingerprinting probes based on Jeffreys minisatellite core or those exhibiting similarities with this G-rich core consensus (GGGCAGGAXG), such as the (GTG)5 simple repeat (Schafer et-al 1988) or random G-rich...
